Does neuronal expression of GDNF effectively protect dopaminergic neurons in a rat model of Parkinson's disease?

被引：0
|
作者：
N A Do Thi
P Saillour
L Ferrero
T Paunio
J Mallet
机构：
[1] Laboratoire de Genetique Moleculaire de la Neurotransmission et des Processus Neurodegeneratifs,Department of Molecular Medicine
[2] CNRS,undefined
[3] UMR 7091,undefined
[4] Bat. CERVI,undefined
[5] Hopital Pitie-Salpetriere,undefined
[6] Gencell SAS,undefined
[7] Vitry sur Seine,undefined
[8] Biomedicum,undefined
来源：
Gene Therapy | 2007年 / 14卷
关键词：
adenoviral vector; Parkinson's disease; Glial cell line-derived neurotrophic factor; NSE promoter;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The transfer of the Glial cell line-derived neurotrophic factor (GDNF) gene to the central nervous system by a recombinant adenoviral vector (Ad) was studied. We constructed the adenovirus vector Ad-NSE-GDNF from which the E1, E3/E4 regions of Ad5 have been deleted and in which the GDNF gene was under the control of a neuron-specific enolase (NSE) promoter. The vector was injected into the striatum of a rat model of Parkinson's disease. We found that (i) the NSE promoter can restrict transgene expression in neurons; (ii) Ad-NSE-GDNF significantly protected dopaminergic (DA) neurons in the substantia nigra (SN) but did not reverse the impairments of amphetamine-induced rotational behavior in lesioned rats.
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页码：441 / 450
页数：9
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