Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

被引：0

作者：

Yoshinori Fukazawa

Haesun Park

Mark J Cameron

Francois Lefebvre

Richard Lum

Noel Coombes

Eisa Mahyari

Shoko I Hagen

Jin Young Bae

Marcelo Delos Reyes III

Tonya Swanson

Alfred W Legasse

Andrew Sylwester

Scott G Hansen

Andrew T Smith

Petra Stafova

Rebecca Shoemaker

Yuan Li

Kelli Oswald

Michael K Axthelm

Adrian McDermott

Guido Ferrari

David C Montefiori

Paul T Edlefsen

Michael Piatak

Jeffrey D Lifson

Rafick P Sékaly

Louis J Picker

机构：

[1] Vaccine and Gene Therapy Institute,Vaccine and Infectious Disease Division

[2] Oregon Health and Science University,undefined

[3] Oregon National Primate Research Center,undefined

[4] Oregon Health and Science University,undefined

[5] Vaccine and Gene Therapy Institute-Florida,undefined

[6] AIDS and Cancer Virus Program,undefined

[7] SAIC Frederick,undefined

[8] Inc.,undefined

[9] Frederick National Laboratory for Cancer Research,undefined

[10] Vaccine Research Institute,undefined

[11] US National Institute of Allergy and Infectious Diseases,undefined

[12] Duke University Medical Center,undefined

[13] Statistical Center for HIV/AIDS Research and Prevention,undefined

[14] Fred Hutchinson Cancer Research Center,undefined

来源：

Nature Medicine | 2012年 / 18卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Live attenuated SIV vaccines protect nonhuman primates from infection with pathogenic wild-type SIV, but the crucial mechanisms have not been clear. In this issue, Louis Picker and colleagues show that protection by live attenuated vaccines against intravenous SIV challenge in rhesus macaques is associated with SIV-specific T cell response in the lymph nodes, and not the blood, and persistent SIV replication in lymph node follicular T helper cells.

引用

页码：1673 / 1681

页数：8

共 50 条

[31] The role of lymph node stromal cells in regulating T cell responses
Turley, Shannon
CLINICAL IMMUNOLOGY, 2008, 127 : S11 - S11
[32] Occult replication of a conditionally-live attenuated SIV profoundly upregulates T effector memory cell frequency
Maria Manoussaka
Richard Stebbings
Neil Berry
Atze Das
Ben Berkhout
Neil Almond
Martin Cranage
Retrovirology, 8 (Suppl 2)
[33] REGULATED SYSTEMIC CD8+T CELL RESPONSES ARE ASSOCIATED WITH THE PROTECTIVE IMMUNITY TO SIV CONFERRED BY VACCINATION WITH LIVE NEF-ATTENUATED VIRUS
George, Michael D.
Hu, William
Billingsly, Michael J.
Sankaran-Walters, Sumathi
Johnson, Paul
Dandekar, Satya
JOURNAL OF MEDICAL PRIMATOLOGY, 2013, 42 (05) : 274 - 275
[34] Occult Replication of a Conditionally-Live Attenuated SIV Profoundly Upregulates T Effector Memory Cell Frequency
Manoussaka, M.
Stebbings, R.
Berry, N.
Das, A.
Berkhout, B.
Almond, N.
Cranage, M. P.
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2011, 27 (10) : A127 - A127
[35] Cellular immune responses induced by live, attenuated SIV contribute to vaccine-induced protection against SIV challenge
不详
JOURNAL OF MEDICAL PRIMATOLOGY, 2004, 33 (5-6) : 288 - 288
[36] Distinct Cross-reactive B-Cell Responses to Live Attenuated and Inactivated Influenza Vaccines
Sasaki, Sanae
Holmes, Tyson H.
Albrecht, Randy A.
Garcia-Sastre, Adolfo
Dekker, Cornelia L.
He, Xiao-Song
Greenberg, Harry B.
JOURNAL OF INFECTIOUS DISEASES, 2014, 210 (06): : 865 - 874
[37] A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge
Hansen, Scott G.
Marshall, Emily E.
Malouli, Daniel
Ventura, Abigail B.
Hughes, Colette M.
Ainslie, Emily
Ford, Julia C.
Morrow, David
Gilbride, Roxanne M.
Bae, Jin Y.
Legasse, Alfred W.
Oswald, Kelli
Shoemaker, Rebecca
Berkemeier, Brian
Bosche, William J.
Hull, Michael
Womack, Jennie
Shao, Jason
Edlefsen, Paul T.
Reed, Jason S.
Burwitz, Ben J.
Sacha, Jonah B.
Axthelm, Michael K.
Frueh, Klaus
Lifson, Jeffrey D.
Picker, Louis J.
SCIENCE TRANSLATIONAL MEDICINE, 2019, 11 (501)
[38] Live and Inactivated Influenza Vaccines Induce Similar Humoral Responses, but Only Live Vaccines Induce Diverse T-Cell Responses in Young Children
Hoft, Daniel F.
Babusis, Elizabeth
Worku, Shewangizaw
Spencer, Charles T.
Lottenbach, Kathleen
Truscott, Steven M.
Abate, Getahun
Sakala, Isaac G.
Edwards, Kathryn M.
Creech, C. Buddy
Gerber, Michael A.
Bernstein, David I.
Newman, Frances
Graham, Irene
Anderson, Edwin L.
Belshe, Robert B.
JOURNAL OF INFECTIOUS DISEASES, 2011, 204 (06): : 845 - 853
[39] Cytotoxic T lymphocytes do not mediate the protection conferred by a live attenuated SIV vaccine
不详
JOURNAL OF MEDICAL PRIMATOLOGY, 2005, 34 (5-6) : 325 - 325
[40] Lymph node stromal cell responses to perinatal T cell waves, a temporal atlas
Jayewickreme, Teshika
Benoist, Christophe
Mathis, Diane
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 120 (51)

← 1 2 3 4 5 →