Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

被引：0

作者：

Yoshinori Fukazawa

Haesun Park

Mark J Cameron

Francois Lefebvre

Richard Lum

Noel Coombes

Eisa Mahyari

Shoko I Hagen

Jin Young Bae

Marcelo Delos Reyes III

Tonya Swanson

Alfred W Legasse

Andrew Sylwester

Scott G Hansen

Andrew T Smith

Petra Stafova

Rebecca Shoemaker

Yuan Li

Kelli Oswald

Michael K Axthelm

Adrian McDermott

Guido Ferrari

David C Montefiori

Paul T Edlefsen

Michael Piatak

Jeffrey D Lifson

Rafick P Sékaly

Louis J Picker

机构：

[1] Vaccine and Gene Therapy Institute,Vaccine and Infectious Disease Division

[2] Oregon Health and Science University,undefined

[3] Oregon National Primate Research Center,undefined

[4] Oregon Health and Science University,undefined

[5] Vaccine and Gene Therapy Institute-Florida,undefined

[6] AIDS and Cancer Virus Program,undefined

[7] SAIC Frederick,undefined

[8] Inc.,undefined

[9] Frederick National Laboratory for Cancer Research,undefined

[10] Vaccine Research Institute,undefined

[11] US National Institute of Allergy and Infectious Diseases,undefined

[12] Duke University Medical Center,undefined

[13] Statistical Center for HIV/AIDS Research and Prevention,undefined

[14] Fred Hutchinson Cancer Research Center,undefined

来源：

Nature Medicine | 2012年 / 18卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Live attenuated SIV vaccines protect nonhuman primates from infection with pathogenic wild-type SIV, but the crucial mechanisms have not been clear. In this issue, Louis Picker and colleagues show that protection by live attenuated vaccines against intravenous SIV challenge in rhesus macaques is associated with SIV-specific T cell response in the lymph nodes, and not the blood, and persistent SIV replication in lymph node follicular T helper cells.

引用

页码：1673 / 1681

页数：8

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