Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

被引：0
|
作者：
Yoshinori Fukazawa
Haesun Park
Mark J Cameron
Francois Lefebvre
Richard Lum
Noel Coombes
Eisa Mahyari
Shoko I Hagen
Jin Young Bae
Marcelo Delos Reyes III
Tonya Swanson
Alfred W Legasse
Andrew Sylwester
Scott G Hansen
Andrew T Smith
Petra Stafova
Rebecca Shoemaker
Yuan Li
Kelli Oswald
Michael K Axthelm
Adrian McDermott
Guido Ferrari
David C Montefiori
Paul T Edlefsen
Michael Piatak
Jeffrey D Lifson
Rafick P Sékaly
Louis J Picker
机构：
[1] Vaccine and Gene Therapy Institute,Vaccine and Infectious Disease Division
[2] Oregon Health and Science University,undefined
[3] Oregon National Primate Research Center,undefined
[4] Oregon Health and Science University,undefined
[5] Vaccine and Gene Therapy Institute-Florida,undefined
[6] AIDS and Cancer Virus Program,undefined
[7] SAIC Frederick,undefined
[8] Inc.,undefined
[9] Frederick National Laboratory for Cancer Research,undefined
[10] Vaccine Research Institute,undefined
[11] US National Institute of Allergy and Infectious Diseases,undefined
[12] Duke University Medical Center,undefined
[13] Statistical Center for HIV/AIDS Research and Prevention,undefined
[14] Fred Hutchinson Cancer Research Center,undefined
来源：
Nature Medicine | 2012年 / 18卷
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摘要：
Live attenuated SIV vaccines protect nonhuman primates from infection with pathogenic wild-type SIV, but the crucial mechanisms have not been clear. In this issue, Louis Picker and colleagues show that protection by live attenuated vaccines against intravenous SIV challenge in rhesus macaques is associated with SIV-specific T cell response in the lymph nodes, and not the blood, and persistent SIV replication in lymph node follicular T helper cells.
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页码：1673 / 1681
页数：8
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