MicroRNA expression profiling on arrays enhanced with locked nucleic acids

被引：0

作者：

Roberts P. ^{[1
]}

机构：

[1] Exiqon A/S, DK-2950 Vedbæk

来源：

Nature Methods | 2006年 / 3卷 / 4期

关键词：

D O I：

10.1038/nmeth869

中图分类号：

学科分类号：

摘要：

Here we describe a new array system (miRCURY™ LNA Array) for global microRNA (miRNA) profiling of biological samples. The miRCURY LNA Array system uses locked nucleic acid (LNA™), a high-affinity nucleotide analog, to enhance the array capture probes, giving them high sensitivity and excellent selectivity for miRNA targets. We have simultaneously developed a straightforward method for labeling miRNAs in a sample. As a result, the miRCURY LNA Array system can provide sensitiveand accurate profiling of miRNAs while requiring less sample and keeping sample handling stepsto a minimum. © 2006 Nature Publishing Group.

引用

页码：iii / iv

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