A shared neural basis underlying psychiatric comorbidity

被引：0

作者：

Chao Xie

Shitong Xiang

Chun Shen

Xuerui Peng

Jujiao Kang

Yuzhu Li

Wei Cheng

Shiqi He

Marina Bobou

M. John Broulidakis

Betteke Maria van Noort

Zuo Zhang

Lauren Robinson

Nilakshi Vaidya

Jeanne Winterer

Yuning Zhang

Sinead King

Tobias Banaschewski

Gareth J. Barker

Arun L. W. Bokde

Uli Bromberg

Christian Büchel

Herta Flor

Antoine Grigis

Hugh Garavan

Penny Gowland

Andreas Heinz

Bernd Ittermann

Hervé Lemaître

Jean-Luc Martinot

Marie-Laure Paillère Martinot

Frauke Nees

Dimitri Papadopoulos Orfanos

Tomáš Paus

Luise Poustka

Juliane H. Fröhner

Ulrike Schmidt

Julia Sinclair

Michael N. Smolka

Argyris Stringaris

Henrik Walter

Robert Whelan

Sylvane Desrivières

Barbara J. Sahakian

Trevor W. Robbins

Gunter Schumann

Tianye Jia

Jianfeng Feng

机构：

[1] Fudan University,Institute of Science and Technology for Brain

[2] Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University),Inspired Intelligence

[3] Ministry of Education,Faculty of Psychology

[4] Technische Universität Dresden,School of Health Sciences

[5] The University of Manchester,Social Genetic and Developmental Psychiatry Centre

[6] Institute of Psychiatry,Clinical and Experimental Sciences, Faculty of Medicine

[7] Psychology and Neuroscience,Department of Psychology

[8] King’s College London,Department of Psychological Medicine, Section for Eating Disorders

[9] University of Southampton,Department of Psychiatry and Neurosciences

[10] MSB Medical School Berlin,Department of Education and Psychology

[11] Institute of Psychiatry,Psychology Department

[12] Psychology and Neuroscience,Department of Child and Adolescent Psychiatry and Psychotherapy

[13] King’s College London,Department of Neuroimaging

[14] South London and Maudsley NHS Foundation Trust,Discipline of Psychiatry

[15] Charité–Universitätsmedizin Berlin,Department of Psychology, School of Social Sciences

[16] corporate member of Freie Universität Berlin,Departments of Psychiatry and Psychology

[17] Humboldt-Universität zu Berlin,Sir Peter Mansfield Imaging Centre School of Physics and Astronomy

[18] and Berlin Institute of Health,AP

[19] Freie Universität Berlin,HP, Sorbonne Université, Department of Child and Adolescent Psychiatry

[20] University of Southampton,Institute of Medical Psychology and Medical Sociology

[21] School of Medicine,Department of Psychiatry and Neuroscience and Centre Hospitalier Universitaire Sainte

[22] Center for Neuroimaging,Justine

[23] Cognition and Genomics,Department of Child and Adolescent Psychiatry and Psychotherapy

[24] National University of Ireland (NUI) Galway,Department of Psychiatry and Neuroimaging Center

[25] Central Institute of Mental Health,Division of Psychiatry and Department of Clinical, Educational & Health Psychology

[26] Medical Faculty Mannheim,School of Psychology and Global Brain Health Institute

[27] Heidelberg University,Department of Psychiatry and Behavioural and Clinical Neuroscience Institute

[28] Institute of Psychiatry,Department of Psychology and Behavioural and Clinical Neuroscience Institute

[29] Psychology and Neuroscience,Department of Sports and Health Sciences

[30] King’s College London,PONS Centre, Institute for Science and Technology of Brain

[31] School of Medicine and Trinity College Institute of Neuroscience,inspired Intelligence (ISTBI)

[32] Trinity College Dublin,School of Mathematical Sciences and Centre for Computational Systems Biology

[33] University Medical Centre Hamburg-Eppendorf,Department of Computer Science

[34] Institute of Cognitive and Clinical Neuroscience,undefined

[35] Central Institute of Mental Health,undefined

[36] Medical Faculty Mannheim,undefined

[37] Heidelberg University,undefined

[38] University of Mannheim,undefined

[39] NeuroSpin,undefined

[40] C.E.A.,undefined

[41] Université Paris-Saclay,undefined

[42] University of Vermont,undefined

[43] University of Nottingham,undefined

[44] Physikalisch-Technische Bundesanstalt (PTB),undefined

[45] Institut des Maladies Neurodégénératives,undefined

[46] UMR 5293,undefined

[47] CNRS,undefined

[48] CEA,undefined

[49] Université de Bordeaux,undefined

[50] Institut National de la Santé et de la Recherche Médicale,undefined

来源：

Nature Medicine | 2023年 / 29卷

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学科分类号：

摘要：

Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetically determined, delayed development of the prefrontal cortex that further leads to poor executive function. We also show this NP factor to be reproducible in multiple developmental periods, from preadolescence to early adulthood, and generalizable to the resting-state connectome and clinical samples (the ADHD-200 Sample and the STRATIFY & ESTRA Project). In conclusion, we identify a reproducible and general neural basis underlying symptoms of multiple mental health disorders, bridging multidimensional evidence from behavioral, neuroimaging and genetic substrates. These findings may help to develop new therapeutic interventions for psychiatric comorbidities.

引用

页码：1232 / 1242

页数：10

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