Kinesin binding as a shared pathway underlying the genetic basis of male factor infertility and insomnia

被引:0
|
作者
Adami, Luana N. G. [1 ,2 ]
Moyses-Oliveira, Mariana [1 ]
Tufik, Sergio [1 ,2 ]
Andersen, Monica L. [1 ,2 ]
机构
[1] Assoc Fundo Incent Pesquisa, Sleep Inst, Sao Paulo, Brazil
[2] Univ Fed Sao Paulo, Dept Psicobiol, Rua Napoleao Barros, 925 Vila Clementino, BR-04024002 Sao Paulo, Brazil
来源
F&S SCIENCE | 2024年 / 5卷 / 03期
基金
巴西圣保罗研究基金会;
关键词
Sleep; sperm; microtubule; circadian; neuron; SLEEP; DISORDER; GABA;
D O I
10.1016/j.xfss.2024.06.003
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To study whether male factor infertility and insomnia share genetic risk variants and identify any molecular, cellular, and biologic interactions between these traits. Design: The in silico study was performed. Two lists of genetic variants were manually curated through a literature review, one of those associated with male factor infertility and the other with insomnia. Genes were assigned to these variants to compose male factor infertility-associated (454 genes) and insomnia-associated (921 genes) gene lists. Setting: Not applicable. Patient(s): Not applicable. Intervention(s): Not applicable. Main Outcome Measure(s): Enrichment of biologic pathways and protein-protein interaction analysis. Result(s): Twenty-eight genes were common to both lists, representing a greater overlap than would be expected by chance. In the 28 genes contained in the intersection list, there was a significant enrichment of pathways related to kinesin binding. A protein-protein interaction analysis using the intersection list as input retrieved 25 nodes and indicated that two of them were kinesin-related proteins (PLEKHM2 and KCL1). Conclusion(s): The shared male factor infertility and insomnia genes, and the biologic pathways highlighted in this study, suggest that further functional investigations into the interplay between fertility and sleep are warranted. (F S Sci (R) 2024;5:225-31. (c) 2024 by American Society for Reproductive Medicine.)
引用
收藏
页码:225 / 231
页数:7
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