Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

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作者
机构
[1] University of Queensland Diamantina Institute,Department of Rheumatology
[2] Translational Research Institute,Department of Medicine, Division of Rheumatology
[3] National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit,Department of Medicine/Rheumatology
[4] Nuffield Orthopaedic Centre,Division of Rheumatology
[5] Hanyang University Hospital for Rheumatic Diseases,Division of Medicine
[6] Eulji University Hospital,Department of Medical Genetics
[7] Cedars-Sinai Medical Center,Department of Immunology
[8] National Institute of Arthritis and Musculoskeletal and Skin Diseases,Department of Rheumatology
[9] US National Institutes of Health,Department of Rheumatology and Immunology
[10] Rheumatology and Clinical Immunogenetics,Department of Rheumatology
[11] University of Texas Health Science Center at Houston,Department of Rheumatology
[12] Institut Cochin,Department of Medicine
[13] Université Paris–Descartes,Division of Rheumatology
[14] Centre National de Recherche Scientifique (CNRS) Unité Mixte de Recherhce (UMR) 8104,Rheumatology Department
[15] Institut National de la Santé et de la Recherche Médicale (INSERM) U1016,Rheumatology Department
[16] Ambroise Paré Hospital,Rheumatology Department
[17] Assistance Publique–Hôpitaux de Paris,Department of Immunology
[18] Versailles-Saint-Quentin en Yvelines University,Department of Rheumatology
[19] University Hospital North Norway,Department of Medicine
[20] Royal Darwin Hospital,Division of Rheumatology
[21] University of Oslo and Oslo University Hospital,Department of Medicine
[22] Oslo University Hospital,Department of Medical Microbiology and Infection Control
[23] University Hospital Oslo,Department of Rheumatology
[24] Centre for Vascular Prevention,Department of Medicine, Division of Allergy
[25] Danube-University Krems,Division of Rheumatology
[26] Diabetes Prevention Unit,Department of Laboratory Medicine
[27] National Institute for Health and Welfare,Department of Immunology and Transfusion Medicine
[28] King Abdulaziz University,undefined
[29] Paijat-Hame Central Hospital,undefined
[30] Shanghai Changzheng Hospital,undefined
[31] Second Military Medical University,undefined
[32] Ghent University Hospital,undefined
[33] Hospital General de México,undefined
[34] Faculty of Medicine,undefined
[35] Universidad Nacional Autónoma de México,undefined
[36] Dunedin School of Medicine,undefined
[37] University of Otago,undefined
[38] Toronto Western Hospital,undefined
[39] Queensland Institute of Medical Research,undefined
[40] Royal Brisbane Hospital,undefined
[41] Hospital Puerta de Hierro,undefined
[42] Complejo Hospitalario La Coruña,undefined
[43] Instituto de Investigación Biomédica A Coruña (INIBIC),undefined
[44] Hospital Marqués de Valcecilla,undefined
[45] Instituto de Formación e Investigación Marqués de Valcecillas (IFIMAV),undefined
[46] Asturias Central University Hospital,undefined
[47] Fundación Renal Iñigo Alvarez de Toledo,undefined
[48] Wellcome Trust Sanger Institute,undefined
[49] Wellcome Trust Centre for Human Genetics,undefined
[50] University of Oxford,undefined
来源
Nature Genetics | 2013年 / 45卷
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摘要
Matthew Brown and colleagues identify multiple susceptibility variants for ankylosing spondylitis through an association study based on high-density genotyping of immune-related loci. Their findings implicate numerous biological pathways in the pathogenesis of this disease and highlight shared risk factors with other autoimmune diseases.
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页码:730 / 738
页数:8
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