Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

被引：0

作者：

机构：

[1] University of Queensland Diamantina Institute,Department of Rheumatology

[2] Translational Research Institute,Department of Medicine, Division of Rheumatology

[3] National Institute for Health Research (NIHR) Oxford Musculoskeletal Biomedical Research Unit,Department of Medicine/Rheumatology

[4] Nuffield Orthopaedic Centre,Division of Rheumatology

[5] Hanyang University Hospital for Rheumatic Diseases,Division of Medicine

[6] Eulji University Hospital,Department of Medical Genetics

[7] Cedars-Sinai Medical Center,Department of Immunology

[8] National Institute of Arthritis and Musculoskeletal and Skin Diseases,Department of Rheumatology

[9] US National Institutes of Health,Department of Rheumatology and Immunology

[10] Rheumatology and Clinical Immunogenetics,Department of Rheumatology

[11] University of Texas Health Science Center at Houston,Department of Rheumatology

[12] Institut Cochin,Department of Medicine

[13] Université Paris–Descartes,Division of Rheumatology

[14] Centre National de Recherche Scientifique (CNRS) Unité Mixte de Recherhce (UMR) 8104,Rheumatology Department

[15] Institut National de la Santé et de la Recherche Médicale (INSERM) U1016,Rheumatology Department

[16] Ambroise Paré Hospital,Rheumatology Department

[17] Assistance Publique–Hôpitaux de Paris,Department of Immunology

[18] Versailles-Saint-Quentin en Yvelines University,Department of Rheumatology

[19] University Hospital North Norway,Department of Medicine

[20] Royal Darwin Hospital,Division of Rheumatology

[21] University of Oslo and Oslo University Hospital,Department of Medicine

[22] Oslo University Hospital,Department of Medical Microbiology and Infection Control

[23] University Hospital Oslo,Department of Rheumatology

[24] Centre for Vascular Prevention,Department of Medicine, Division of Allergy

[25] Danube-University Krems,Division of Rheumatology

[26] Diabetes Prevention Unit,Department of Laboratory Medicine

[27] National Institute for Health and Welfare,Department of Immunology and Transfusion Medicine

[28] King Abdulaziz University,undefined

[29] Paijat-Hame Central Hospital,undefined

[30] Shanghai Changzheng Hospital,undefined

[31] Second Military Medical University,undefined

[32] Ghent University Hospital,undefined

[33] Hospital General de México,undefined

[34] Faculty of Medicine,undefined

[35] Universidad Nacional Autónoma de México,undefined

[36] Dunedin School of Medicine,undefined

[37] University of Otago,undefined

[38] Toronto Western Hospital,undefined

[39] Queensland Institute of Medical Research,undefined

[40] Royal Brisbane Hospital,undefined

[41] Hospital Puerta de Hierro,undefined

[42] Complejo Hospitalario La Coruña,undefined

[43] Instituto de Investigación Biomédica A Coruña (INIBIC),undefined

[44] Hospital Marqués de Valcecilla,undefined

[45] Instituto de Formación e Investigación Marqués de Valcecillas (IFIMAV),undefined

[46] Asturias Central University Hospital,undefined

[47] Fundación Renal Iñigo Alvarez de Toledo,undefined

[48] Wellcome Trust Sanger Institute,undefined

[49] Wellcome Trust Centre for Human Genetics,undefined

[50] University of Oxford,undefined

来源：

Nature Genetics | 2013年 / 45卷

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摘要：

Matthew Brown and colleagues identify multiple susceptibility variants for ankylosing spondylitis through an association study based on high-density genotyping of immune-related loci. Their findings implicate numerous biological pathways in the pathogenesis of this disease and highlight shared risk factors with other autoimmune diseases.

引用

页码：730 / 738

页数：8

共 46 条

[1] Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
Cortes, Adrian
Hadler, Johanna
Pointon, Jenny P.
Robinson, Philip C.
Karaderi, Tugce
Leo, Paul
Cremin, Katie
Pryce, Karena
Harris, Jessica
Lee, Seunghun
Joo, Kyung Bin
Shim, Seung-Cheol
Weisman, Michael
Ward, Michael
Zhou, Xiaodong
Garchon, Henri-Jean
Chiocchia, Gilles
Nossent, Johannes
Lie, Benedicte A.
Forre, Oystein
Tuomilehto, Jaakko
Laiho, Kari
Jiang, Lei
Liu, Yu
Wu, Xin
Bradbury, Linda A.
Elewaut, Dirk
Burgos-Vargas, Ruben
Stebbings, Simon
Appleton, Louise
Farrah, Claire
Lau, Jonathan
Kenna, Tony J.
Haroon, Nigil
Ferreira, Manuel A.
Yang, Jian
Mulero, Juan
Fernandez-Sueiro, Jose Luis
Gonzalez-Gay, Miguel A.
Lopez-Larrea, Carlos
Deloukas, Panos
Donnelly, Peter
Bowness, Paul
Gafney, Karl
Gaston, Hill
Gladman, Dafna D.
Rahman, Proton
Maksymowych, Walter P.
Xu, Huji
Crusius, J. Bart A.
NATURE GENETICS, 2013, 45 (07) : 730 - +
[2] Accounting For Parental Load and Identification Of Multiple Risk Variants For Anti-Ro Congenital Heart Block Through High-Density Genotyping Of Immune-Related Loci
Clancy, Robert M.
Buyon, Jill P.
Costedoat-Chalumeau, Nathalie
Brucato, Antonio
Levesque, Kateri
Ramoni, Veronique
Marion, Miranda C.
Comeau, Mary
Sajuthi, Satria
Ramos, Paula S.
Kimberly, Robert P.
Howard, Timothy D.
Langefeld, Carl D.
ARTHRITIS AND RHEUMATISM, 2013, 65 : S1226 - S1226
[3] High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry
Sun, Celi
Molineros, Julio E.
Looger, Loren L.
Zhou, Xu-jie
Kim, Kwangwoo
Okada, Yukinori
Ma, Jianyang
Qi, Yuan-yuan
Kim-Howard, Xana
Motghare, Prasenjeet
Bhattarai, Krishna
Adler, Adam
Bang, So-Young
Lee, Hye-Soon
Kim, Tae-Hwan
Kang, Young Mo
Suh, Chang-Hee
Chung, Won Tae
Park, Yong-Beom
Choe, Jung-Yoon
Shim, Seung Cheol
Kochi, Yuta
Suzuki, Akari
Kubo, Michiaki
Sumida, Takayuki
Yamamoto, Kazuhiko
Lee, Shin-Seok
Kim, Young Jin
Han, Bok-Ghee
Dozmorov, Mikhail
Kaufman, Kenneth M.
Wren, Jonathan D.
Harley, John B.
Shen, Nan
Chua, Kek Heng
Zhang, Hong
Bae, Sang-Cheol
Nath, Swapan K.
NATURE GENETICS, 2016, 48 (03) : 323 - 330
[4] High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry
Celi Sun
Julio E Molineros
Loren L Looger
Xu-jie Zhou
Kwangwoo Kim
Yukinori Okada
Jianyang Ma
Yuan-yuan Qi
Xana Kim-Howard
Prasenjeet Motghare
Krishna Bhattarai
Adam Adler
So-Young Bang
Hye-Soon Lee
Tae-Hwan Kim
Young Mo Kang
Chang-Hee Suh
Won Tae Chung
Yong-Beom Park
Jung-Yoon Choe
Seung Cheol Shim
Yuta Kochi
Akari Suzuki
Michiaki Kubo
Takayuki Sumida
Kazuhiko Yamamoto
Shin-Seok Lee
Young Jin Kim
Bok-Ghee Han
Mikhail Dozmorov
Kenneth M Kaufman
Jonathan D Wren
John B Harley
Nan Shen
Kek Heng Chua
Hong Zhang
Sang-Cheol Bae
Swapan K Nath
Nature Genetics, 2016, 48 : 323 - 330
[5] Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis
Westerlind, Helga
Mellander, Marie-Rose
Bresso, Francesca
Munch, Andreas
Bonfiglio, Ferdinando
Assadi, Ghazaleh
Rafter, Joseph
Huebenthal, Matthias
Lieb, Wolfgang
Kallberg, Henrik
Brynedal, Boel
Padyukov, Leonid
Halfvarson, Jonas
Torkvist, Leif
Bjork, Jan
Andreasson, Anna
Agreus, Lars
Almer, Sven
Miehlke, Stephan
Madisch, Ahmed
Ohlsson, Bodil
Lofberg, Robert
Hultcrantz, Rolf
Franke, Andre
D'Amato, Mauro
GUT, 2017, 66 (03) : 421 - 428
[6] New narcolepsy susceptibility loci identified through dense genotyping of immune-related loci
Faraco, J.
Lin, L.
Mignot, E.
JOURNAL OF SLEEP RESEARCH, 2012, 21 : 40 - 40
[7] High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci
Kim, Kwangwoo
Bang, So-Young
Lee, Hye-Soon
Cho, Soo-Kyung
Choi, Chan-Bum
Sung, Yoon-Kyoung
Kim, Tae-Hwan
Jun, Jae-Bum
Yoo, Dae Hyun
Kang, Young Mo
Kim, Seong-Kyu
Suh, Chang-Hee
Shim, Seung-Cheol
Lee, Shin-Seok
Lee, Jisoo
Chung, Won Tae
Choe, Jung-Yoon
Shin, Hyoung Doo
Lee, Jong-Young
Han, Bok-Ghee
Nath, Swapan K.
Eyre, Steve
Bowes, John
Pappas, Dimitrios A.
Kremer, Joel M.
Gonzalez-Gay, Miguel A.
Rodriguez-Rodriguez, Luis
Arlestig, Lisbeth
Okada, Yukinori
Diogo, Dorothee
Liao, Katherine P.
Karlson, Elizabeth W.
Raychaudhuri, Soumya
Rantapaa-Dahlqvist, Solbritt
Martin, Javier
Klareskog, Lars
Padyukov, Leonid
Gregersen, Peter K.
Worthington, Jane
Greenberg, Jeffrey D.
Plenge, Robert M.
Bae, Sang-Cheol
ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 (03)
[8] Immunochip-Based Analysis: High-Density Genotyping of Immune-Related Loci Sheds Further Light on the Autoimmune Genetic Architecture of Alopecia Areata
Redler, Silke
Angisch, Marina
Heilmann, Stefanie
Wolf, Sabrina
Barth, Sandra
Basmanav, Buket F.
Giehl, Kathrin A.
Hanneken, Sandra
Eigelshoven, Sibylle
Mangold, Elisabeth
Kruse, Roland
Blaumeiser, Bettina
Boehm, Markus
Knapp, Michael
Bartels, Natalie Garcia
Lutz, Gerhard
Wolff, Hans
Blume-Peytavi, Ulrike
Noethen, Markus M.
Becker, Tim
Betz, Regina C.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2015, 135 (03) : 919 - 921
[9] High Density Genotyping Of Immune-Related Disease Genes Identifies 7 New Susceptibility Loci For Behcets Disease
Takeuchi, Masaki
Mizuki, Nobuhisa
Meguro, Akira
Ombrello, Michael J.
Satorius, Colleen
Kirino, Yohei
Kawagoe, Tatsukata
Ustek, Duran
Tugal-tutkun, Ilknur
Seyahi, Emire
Ozyazgan, Yilmaz
Ohno, Shigeaki
Ueda, Atsuhisa
Ishigatsubo, Yoshiaki
Gul, Ahmet
Kastner, Daniel L.
Remmers, Elaine
ARTHRITIS AND RHEUMATISM, 2013, 65 : S721 - S722
[10] High-Density Genotyping of Risk Loci in African Americans with RA.
Danila, Maria I.
Reynolds, Richard
Yan, Qi
Liu, Nianjun
Gregersen, Peter K.
Arnett, Donna K.
Bridges, S. Louis, Jr.
ARTHRITIS & RHEUMATOLOGY, 2014, 66 : S1069 - S1070

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