Gene Expression Profiles of ABC Transporters and Cytochrome P450 3A in Caco-2 and Human Colorectal Cancer Cell Lines

被引：0
|
作者：
Tsutomu Nakamura
Toshiyuki Sakaeda
Nobuko Ohmoto
Yuka Moriya
Chiho Komoto
Toshiro Shirakawa
Akinobu Gotoh
Masafumi Matsuo
Katsuhiko Okumura
机构：
[1] Kobe University,Department of Hospital Pharmacy, School of Medicine
[2] Kobe University,Department of Urology, School of Medicine
[3] Kobe University,Departments of Clinical Genetics and International Center for Medical Research, School of Medicine
来源：
Pharmaceutical Research | 2003年 / 20卷
关键词：
MDR1; multidrug resistance-associated protein (MRP); villin; screening model;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The mRNA levels of MDR1 (P-glycoprotein), multidrug resistance-associated proteins (MRP1, MRP2), cytochrome P450 3A (CYP3A) and villin in human colorectal cell lines (HCT-15, LoVo, DLD-1, HCT-116 and SW620) were quantitatively compared with those in Caco-2 cells.
引用
收藏
页码：324 / 327
页数：3
相关论文
共 50 条
  • [31] Expression of human cytochrome p450 3A4 gene in Schizosaccharomyces pombe
    Palabiyik, Bedia
    Karaer, Semian
    Arda, Nazli
    Toker, Sidika Erturk
    Temizkan, Guler
    Kelly, Steven
    Sarikaya, Aysegul Topal
    BIOLOGIA, 2008, 63 (03) : 450 - 454
  • [32] Expression of human cytochrome p450 3A4 gene in Schizosaccharomyces pombe
    Bedia Palabiyik
    Semian Karaer
    Nazli Arda
    Sidika Erturk Toker
    Guler Temizkan
    Steven Kelly
    Aysegul Topal Sarikaya
    Biologia, 2008, 63 : 450 - 454
  • [33] Sources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro
    Greenblatt, David J.
    Venkatakrishnan, Karthik
    Harmatz, Jerold S.
    Parent, Sarah J.
    von Moltke, Lisa L.
    XENOBIOTICA, 2010, 40 (10) : 713 - 720
  • [34] Cocaine metabolism in human fetal and adult liver microsomes is related to cytochrome P450 3A expression
    Ladona, MG
    Gonzalez, ML
    Rane, A
    Peter, RM
    de la Torre, R
    LIFE SCIENCES, 2000, 68 (04) : 431 - 443
  • [35] The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin
    Clarke, TA
    Waskell, LA
    DRUG METABOLISM AND DISPOSITION, 2003, 31 (01) : 53 - 59
  • [36] Role of cytochrome P450 3A in the metabolism of mefloquine in human and animal hepatocytes
    Fontaine, F
    de Sousa, G
    Burcham, PC
    Duchêne, P
    Rahmani, R
    LIFE SCIENCES, 2000, 66 (22) : 2193 - 2212
  • [37] Cytochrome p450 gene expression in human haemopoietic cells.
    Hodges, VM
    Molloy, GY
    Wickramasinghe, SN
    BRITISH JOURNAL OF HAEMATOLOGY, 1999, 105 : 71 - 71
  • [38] Expression of cytochrome P450 isoforms in immortalised rat hepatocyte cell lines
    Kelly, HT
    Anderson, K
    Hill, L
    Grant, MH
    MacDonald, C
    GENETIC ENGINEER AND BIOTECHNOLOGIST, 1997, 17 (2-3): : 89 - 92
  • [39] Transport properties of paeoniflorin and amygdalin across caco-2 cell monolayer model and their modulation of cytochrome p450 metabolism
    Zhou, Huifen
    He, Yu
    Yang, Jiehong
    Wan, Haofang
    Wang, Liqin
    Wan, Haitong
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020, 33 (04) : 1569 - 1575
  • [40] Establishment of a Stable Human Cell Line, HPL-A3, for Use in Reporter Gene Assays of Cytochrome P450 3A Inducers
    Sekimoto, Masashi
    Sano, Shinsuke
    Hosaka, Takuomi
    Nemoto, Kiyomitsu
    Degawa, Masakuni
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2012, 35 (05) : 677 - 685
12345