Synthesis of chiral 3, 7-diazabicyclo[3.3.1]nonan-9-ones containing (R)-amino acid fragments

被引：0
|
作者：
L. I. Vlasova
N. Z. Baibulatova
R. A. Novikov
Yu. V. Tomilov
V. A. Dokichev
机构：
[1] Russian Academy of Sciences,Ufa Institute of Chemistry
[2] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry
[3] Ufa State Aviation Technical University,undefined
来源：
Russian Chemical Bulletin | 2015年 / 64卷
关键词：
3, 7-diazabicyclo[3.3.1]nonanes; diethyl 1, 3-acetonedicarboxylate; (; )-amino acid esters; formaldehyde; Mannich reaction;
D O I：
暂无
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学科分类号：
摘要：
A reaction of diethyl 1, 3-acetonedicarboxylate with formaldehyde and (R)-alanine, (R)-valine, (R)-leucine, and (R)-phenylalanine ester hydrochlorides gave nonracemic 1, 5-bis(ethoxycarbonyl)-3, 7-diazabicyclo[3.3.1]nonan-9-one derivatives equipped with the corresponding amino acid moieties in 37—85% yield.
引用
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页码：2731 / 2736
页数：5
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