Synthesis of chiral 3, 7-diazabicyclo[3.3.1]nonan-9-ones containing (R)-amino acid fragments

被引：0

作者：

L. I. Vlasova

N. Z. Baibulatova

R. A. Novikov

Yu. V. Tomilov

V. A. Dokichev

机构：

[1] Russian Academy of Sciences,Ufa Institute of Chemistry

[2] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry

[3] Ufa State Aviation Technical University,undefined

来源：

Russian Chemical Bulletin | 2015年 / 64卷

关键词：

3, 7-diazabicyclo[3.3.1]nonanes; diethyl 1, 3-acetonedicarboxylate; (; )-amino acid esters; formaldehyde; Mannich reaction;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A reaction of diethyl 1, 3-acetonedicarboxylate with formaldehyde and (R)-alanine, (R)-valine, (R)-leucine, and (R)-phenylalanine ester hydrochlorides gave nonracemic 1, 5-bis(ethoxycarbonyl)-3, 7-diazabicyclo[3.3.1]nonan-9-one derivatives equipped with the corresponding amino acid moieties in 37—85% yield.

引用

页码：2731 / 2736

页数：5

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