Endogenous Regulatory T Cells Promote M2 Macrophage Phenotype in Diabetic Stroke as Visualized by Optical Imaging

被引：0
|
作者：
Yu Cai
Ting-Ting Xu
Chun-Qiang Lu
Yuan-Yuan Ma
Di Chang
Yi Zhang
Xiao-Chun Gu
Shenghong Ju
机构：
[1] Medical School of Southeast University,Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital
来源：
Translational Stroke Research | 2021年 / 12卷
关键词：
Type 2 diabetes mellitus; Ischemic stroke; Regulatory T cells; M2 macrophages/microglia; Optical imaging;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Regulatory T cells (Tregs) play an immunosuppressive role in various diseases, yet their function remains controversial in stroke and obscure in diabetic stroke. In the present study, Tregs were found downregulated in the peripheral blood of type 2 diabetes mellitus (T2DM) stroke models and patients compared with controls. In ischemic stroke mice (both T2DM and wild type), endogenous Tregs boosted by CD28SA increased CD206+ M2 macrophage/microglia cells, decreased infarct volumes, and improved neurological recovery. Our results demonstrated the potential of boosting Tregs for treating T2DM stroke. Furthermore, we utilized an optical imaging probe (IRD-αCD206) to target M2 macrophage/microglia cells and demonstrated its effect in visualizing M2 macrophage/microglia cells in vivo in ischemic brain tissue.
引用
收藏
页码：136 / 146
页数：10
相关论文
共 50 条
  • [21] Vitamin D Prevents Podocyte Injury via Regulation of Macrophage M1/M2 Phenotype in Diabetic Nephropathy Rats
    Zhang, Xiao-Liang
    Guo, Yin-Feng
    Song, Zhi-Xia
    Zhou, Min
    ENDOCRINOLOGY, 2014, 155 (12) : 4939 - 4950
  • [22] Interleukin-33 Ameliorates Murine Systemic Lupus Erythematosus and Is Associated with Induction of M2 Macrophage Polarisation and Regulatory T Cells
    Mok, Mo Yin
    Law, Ka Sin
    Kong, Wing Yin
    Luo, Cai Yun
    Asfaw, Endale T.
    Chan, Kwok Wah
    Huang, Fang Ping
    Lau, Chak Sing
    Chan, Godfrey Chi Fung
    JOURNAL OF INNATE IMMUNITY, 2023, 15 (01) : 485 - 498
  • [23] HPV16 infection promotes an M2 macrophage phenotype to promote the invasion and metastasis of esophageal squamous cell carcinoma
    Yuan, X.
    Liu, K.
    Li, Y.
    Zhang, A. Z.
    Wang, X. L.
    Jiang, C. H.
    Liang, W. H.
    Zhang, H. J.
    Pang, L. J.
    Li, M.
    Yang, L.
    Qi, Y.
    Zheng, Q.
    Li, F.
    Hu, J. M.
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2021, 23 (11): : 2382 - 2393
  • [24] HPV16 infection promotes an M2 macrophage phenotype to promote the invasion and metastasis of esophageal squamous cell carcinoma
    X. Yuan
    K. Liu
    Y. Li
    A. Z. Zhang
    X. L. Wang
    C. H. Jiang
    W. H. Liang
    H. J. Zhang
    L. J. Pang
    M. Li
    L. Yang
    Y. Qi
    Q. Zheng
    F. Li
    J. M. Hu
    Clinical and Translational Oncology, 2021, 23 : 2382 - 2393
  • [25] Effects of mesenchymal stromal cells on monocyte differentiation to M1 phenotype and M1/M2 macrophage switching
    Shevela, E. Ya.
    Sakhno, L. V.
    Tikhonova, M. A.
    Batorov, E. V.
    Ostanin, A. A.
    Chernykh, E. R.
    BYULLETEN SIBIRSKOY MEDITSINY, 2018, 17 (01): : 167 - 176
  • [26] Phellinus linteus activates Treg cells via FAK to promote M2 macrophage polarization in hepatocellular carcinoma
    Chen, Feihua
    Gong, Mouchun
    Weng, Dengcheng
    Jin, Zhaoqing
    Han, Guofeng
    Yang, Ziqiang
    Han, Junjun
    Wang, Jianjiang
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2024, 73 (01)
  • [27] Human Mesenchymal Stem Cells Promote M2 Macrophage Polarization In Both In Vivo And In Vitro Models Of Ards
    Krasnodembskaya, A. D.
    Morrison, T.
    Gotts, J. E.
    O'Kane, C.
    McAuley, D. F.
    Matthay, M. A.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 189
  • [28] HEPATOCYTES INDUCE A MACROPHAGE PHENOTYPE THAT IS CHARACTERIZED BY EXPRESSION OF A MARKER PROFILE INDICATING M2 MACROPHAGES AND FUNCTIONAL PROPERTIES OF REGULATORY MACROPHAGES
    Wolf, S.
    Haeussinger, D.
    Bode, J. G.
    JOURNAL OF HEPATOLOGY, 2014, 60 (01) : S108 - S108
  • [29] Active vitamin D prevents podocyte injury via regulation of macrophage M1 and M2 phenotype in diabetic nephropathy rats
    郭银凤
    China Medical Abstracts(Internal Medicine), 2014, 31 (03) : 183 - 183
  • [30] ECDI-fixed donor splenocytes prolong skin allograft survival by promoting M2 macrophage polarization and inducing regulatory T cells
    Zhou, Bo
    Zhang, Yuan
    Zhang, Dongliang
    Zhang, Yun
    Xie, Jiangang
    Zhang, Xuexin
    Ding, Jianke
    Su, Yingjun
    Guo, Shuzhong
    Zhuang, Ran
    FASEB BIOADVANCES, 2019, 1 (11) : 706 - 718
12345