Multi-omics on our multitudes

被引：0
|
作者：
Richard A. Voit
Vijay G. Sankaran
机构：
[1] Harvard Medical School,Division of Hematology/Oncology, Boston Children’s Hospital and Department of Pediatric Oncology, Dana
[2] Broad Institute of MIT and Harvard,Farber Cancer Institute
来源：
Nature Genetics | 2022年 / 54卷
关键词：
D O I：
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学科分类号：
摘要：
Clonal expansion of DNMT3A-mutant hematopoietic stem cells is a risk factor for myeloid malignancies and other morbidities. A new study uses multi-modal single-cell genomics to characterize the myeloid differentiation bias of DNMT3A-mutated clones, and finds preferential hypomethylation of binding motifs for key transcriptional regulators.
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页码：1449 / 1450
页数：1
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