ABCB5 is a limbal stem cell gene required for corneal development and repair

被引：0
|
作者：
Bruce R. Ksander
Paraskevi E. Kolovou
Brian J. Wilson
Karim R. Saab
Qin Guo
Jie Ma
Sean P. McGuire
Meredith S. Gregory
William J. B. Vincent
Victor L. Perez
Fernando Cruz-Guilloty
Winston W. Y. Kao
Mindy K. Call
Budd A. Tucker
Qian Zhan
George F. Murphy
Kira L. Lathrop
Clemens Alt
Luke J. Mortensen
Charles P. Lin
James D. Zieske
Markus H. Frank
Natasha Y. Frank
机构：
[1] Schepens Eye Research Institute,Department of Ophthalmology
[2] Massachusetts Eye & Ear Infirmary and Harvard Medical School,Division of Nephrology
[3] Transplant Research Program,Department of Dermatology
[4] Boston Children’s Hospital,Department of Medicine
[5] Brigham and Women’s Hospital,Bascom Palmer Eye Institute and the Department of Ophthalmology
[6] VA Boston Healthcare System,Department of Ophthalmology
[7] University of Miami Miller School of Medicine,Department of Ophthalmology and Visual Sciences
[8] University of Cincinnati Medical Center,Department of Pathology
[9] Stephen A Wynn Institute for Vision Research,Department of Ophthalmology, University of Pittsburgh School of Medicine & Department of Bioengineering
[10] Carver College of Medicine,Division of Genetics
[11] University of Iowa,undefined
[12] Brigham and Women’s Hospital,undefined
[13] University of Pittsburgh Swanson School of Engineering,undefined
[14] Center for Systems Biology and Wellman Center for Photomedicine,undefined
[15] Massachusetts General Hospital and Harvard Medical School,undefined
[16] Harvard Stem Cell Institute,undefined
[17] Harvard Medical School,undefined
[18] Brigham and Women’s Hospital,undefined
来源：
Nature | 2014年 / 511卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The loss of limbal stem cells (LSCs) due to injury or disease is one of the leading causes of blindness; here, the ABCB5 protein is identified as a marker of LSCs in mouse and human eye, and shown to be functionally required for LSC maintenance, corneal development and repair.
引用
收藏
页码：353 / 357
页数：4
相关论文
共 50 条
  • [1] ABCB5 is a limbal stem cell gene required for corneal development and repair
    Ksander, Bruce R.
    Kolovou, Paraskevi E.
    Wilson, Brian J.
    Saab, Karim R.
    Guo, Qin
    Ma, Jie
    McGuire, Sean P.
    Gregory, Meredith S.
    Vincent, William J. B.
    Perez, Victor L.
    Cruz-Guilloty, Fernando
    Kao, Winston W. Y.
    Call, Mindy K.
    Tucker, Budd A.
    Zhan, Qian
    Murphy, George F.
    Lathrop, Kira L.
    Alt, Clemens
    Mortensen, Luke J.
    Lin, Charles P.
    Zieske, James D.
    Frank, Markus H.
    Frank, Natasha Y.
    NATURE, 2014, 511 (7509) : 353 - +
  • [2] The stem cell gene ABCB5 regulates DNA methylation in colorectal cancer
    Guo, Qin
    Frank, Alexander
    Liu, Robert
    Berg, Gretchen
    Xu, Shuyun
    Zhan, Qian
    Murphy, George
    Lian, Christine
    FASEB JOURNAL, 2016, 30
  • [3] Expanded allogeneic limbal stem cell transplantation for diverse severe limbal stem cell deficiency, investigation of ABCB5 and deltaNp63-alpha markers.
    Carlos Serna-Ojeda, Juan
    Graue-Hernandez, Enrique O.
    Navas, Alejandro
    Garcia-Mejia, Mariana
    Ramirez-Miranda, Arturo J.
    Perez, Victor L.
    Garfias, Yonathan
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (12)
  • [4] ABCB5 is a stem cell cycle regulator in MSCs of the skin
    de Vries, J.
    Meier, B.
    Vander Beken, S.
    Jiang, D.
    Frank, N. Y.
    Kampilafkos, P.
    Kluth, A.
    Ganss, C.
    Frank, M. H.
    Scharffetter-Kochanek, K.
    EXPERIMENTAL DERMATOLOGY, 2016, 25 (03) : E45 - E45
  • [5] Human limbal mesenchymal stem cells express ABCB5 and can grow on amniotic membrane
    Shaharuddin, Bakiah
    Osei-Bempong, Charles
    Ahmad, Sajjad
    Rooney, Paul
    Ali, Simi
    Oldershaw, Rachel
    Meeson, Annette
    REGENERATIVE MEDICINE, 2016, 11 (03) : 273 - 286
  • [6] ABCB5: A Novel Cancer Stem Cell Marker in Retinoblastoma
    Kolovou, P. E.
    Frank, N. Y.
    Giani, A.
    Murray, T. G.
    Frank, M. H.
    Ksander, B. R.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (13)
  • [7] Expression of the Stem Cell Marker ABCB5 in Normal and Tumor Tissues
    Saeed, Mohamed E. M.
    Boulos, Joelle C.
    Machel, Kevin
    Andabili, Nasim
    Marouni, Thamail
    Roth, Wilfried
    Efferth, Thomas
    IN VIVO, 2022, 36 (04): : 1651 - 1666
  • [8] Corneal regeneration using autologous ABCB5+skin stem cells for bilateral limbal stem cell deficiency
    Ksander, Bruce
    Sasamoto, Yuzuru
    Hoffmann, Emma
    Korobkina, Katerina
    Frank, Natasha
    Frank, Markus Hermann
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2019, 60 (09)
  • [9] Principal expression of two mRNA isoforms (ABCB5α and ABCB5β) of the ATP-binding cassette transporter gene ABCB5 in melanoma cells and melanocytes
    Chen, KG
    Szakács, G
    Annereau, JP
    Rouzaud, F
    Liang, XJ
    Valencia, JC
    Nagineni, CN
    Hooks, JJ
    Hearing, VJ
    Gottesman, MM
    PIGMENT CELL RESEARCH, 2005, 18 (02): : 102 - 112
  • [10] ABCB5 identifies RPE progenitor cells required for normal retinal development and aging
    Ksander, Bruce
    Hertsenberg, Andrew
    Lewis, Ruth Y.
    Wilson, Brian
    Berg, Gretchen
    Frank, Markus Hermann
    Frank, Natasha Y.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (12)
12345