ABCB5 is a limbal stem cell gene required for corneal development and repair

被引：0
|
作者：
Bruce R. Ksander
Paraskevi E. Kolovou
Brian J. Wilson
Karim R. Saab
Qin Guo
Jie Ma
Sean P. McGuire
Meredith S. Gregory
William J. B. Vincent
Victor L. Perez
Fernando Cruz-Guilloty
Winston W. Y. Kao
Mindy K. Call
Budd A. Tucker
Qian Zhan
George F. Murphy
Kira L. Lathrop
Clemens Alt
Luke J. Mortensen
Charles P. Lin
James D. Zieske
Markus H. Frank
Natasha Y. Frank
机构：
[1] Schepens Eye Research Institute,Department of Ophthalmology
[2] Massachusetts Eye & Ear Infirmary and Harvard Medical School,Division of Nephrology
[3] Transplant Research Program,Department of Dermatology
[4] Boston Children’s Hospital,Department of Medicine
[5] Brigham and Women’s Hospital,Bascom Palmer Eye Institute and the Department of Ophthalmology
[6] VA Boston Healthcare System,Department of Ophthalmology
[7] University of Miami Miller School of Medicine,Department of Ophthalmology and Visual Sciences
[8] University of Cincinnati Medical Center,Department of Pathology
[9] Stephen A Wynn Institute for Vision Research,Department of Ophthalmology, University of Pittsburgh School of Medicine & Department of Bioengineering
[10] Carver College of Medicine,Division of Genetics
[11] University of Iowa,undefined
[12] Brigham and Women’s Hospital,undefined
[13] University of Pittsburgh Swanson School of Engineering,undefined
[14] Center for Systems Biology and Wellman Center for Photomedicine,undefined
[15] Massachusetts General Hospital and Harvard Medical School,undefined
[16] Harvard Stem Cell Institute,undefined
[17] Harvard Medical School,undefined
[18] Brigham and Women’s Hospital,undefined
来源：
Nature | 2014年 / 511卷
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摘要：
The loss of limbal stem cells (LSCs) due to injury or disease is one of the leading causes of blindness; here, the ABCB5 protein is identified as a marker of LSCs in mouse and human eye, and shown to be functionally required for LSC maintenance, corneal development and repair.
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页码：353 / 357
页数：4
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