Electrochemical transfer of [18F]fluoride from [18O]water into organic solvents ready for labeling reactions

被引：0
|
作者：
G. Reischl
W. Ehrlichmann
H.-J. Machulla
机构：
[1] University Hospital,PET
来源：
Journal of Radioanalytical and Nuclear Chemistry | 2002年 / 254卷
关键词：
Physical Chemistry; DMSO; Inorganic Chemistry; Acetonitrile; Fluoride;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
For labeling reactions [18F]fluoride has to be separated from [18O]water and transferred into an organic solvent suitable for nucleophilic substitutions. An electrolytical method is described for depositing [18F]fluoride on a vitreous carbon electrode and releasing it directly into CH3CN or DMSO. In the presence of Et3N×3HF, [18F]fluoride is almost quantitatively released into acetonitrile. When using n.c.a conditions, i.e., Et3N.HCl, desorption of the 18F activity is almost 70% and 60% in acetonitrile and DMSO, respectively, already within 5 minutes.
引用
收藏
页码：29 / 31
页数：2
相关论文
共 50 条
  • [1] Electrochemical transfer of [18F] fluoride from [18O] water into organic solvents ready for labeling reactions
    Reischl, G
    Ehrlichmann, W
    Machulla, HJ
    [J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2002, 254 (01) : 29 - 31
  • [2] Electrochemical transfer of 18F from 18O water to aprotic polar solvent
    Saito, Fuminori
    Nagashima, Yasuyuki
    Goto, Akira
    Iwaki, Masaya
    Takahashi, Nobukazu
    Oka, Takashi
    Inoue, Tomio
    Hyodo, Toshio
    [J]. APPLIED RADIATION AND ISOTOPES, 2007, 65 (05) : 524 - 527
  • [3] Recovery of 18F from [18O] water by electrochemical method
    Saito, F
    Nagashima, Y
    Kurihara, T
    Suzuki, N
    Kim, J
    Wei, L
    Itoh, Y
    Goto, A
    Hyodo, T
    [J]. APPLIED RADIATION AND ISOTOPES, 2001, 55 (06) : 755 - 758
  • [4] Tritium in [18O]water containing [18F]fluoride for [18F]FDG synthesis
    Ito, S
    Saze, T
    Sakane, H
    Ito, S
    Ito, S
    Nishizawa, K
    [J]. APPLIED RADIATION AND ISOTOPES, 2004, 61 (06) : 1179 - 1183
  • [5] Factors affecting the specific activity of [18F]fluoride from a [18O] water target
    Fuechtner, F.
    Preusche, S.
    Maeding, P.
    Zessin, J.
    Steinbach, J.
    [J]. NUKLEARMEDIZIN-NUCLEAR MEDICINE, 2008, 47 (03): : 116 - 119
  • [6] Microfluidic devices for electrode trapping of [18F]fluoride from [18O]water and continuous flow radiosynthesis of [18F]FLT
    He, Ping
    Domarkas, Juozas
    Cawthorne, Christopher
    Archibald, Steve
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2017, 58
  • [7] High-yield electrochemical separation of [18F]fluoride from [18O]water in a transition metal flow cell
    Sadeahi, Saman
    Ly, Jimmy
    Satyamurthy, Nagichettiar
    van Dam, R. Michael
    [J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2011, 54 : S441 - S441
  • [8] Designs and use of silver [18O]water targets for [18F]fluoride production
    Berridge, MS
    Kjellström, R
    [J]. APPLIED RADIATION AND ISOTOPES, 1999, 50 (04) : 699 - 705
  • [9] Tritium contamination in [18O] water containing [18F] fluoride produced by a cyclotron.
    Ito, S
    Saze, T
    Sakane, H
    Ito, S
    Ito, S
    Nishizawa, K
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2003, 44 (05): : 308P - 308P
  • [10] Reusable electrochemical cell for rapid separation of [18F]fluoride from [18O]water for flow-through synthesis of 18F-labeled tracers
    Sadeghi, Saman
    Liang, Vincent
    Cheung, Shilin
    Woo, Suh
    Wu, Curtis
    Ly, Jimmy
    Deng, Yuliang
    Eddings, Mark
    van Dam, R. Michael
    [J]. APPLIED RADIATION AND ISOTOPES, 2013, 75 : 85 - 94
12345