Electrochemical transfer of [18F] fluoride from [18O] water into organic solvents ready for labeling reactions

被引：11
|
作者：
Reischl, G [1 ]
Ehrlichmann, W [1 ]
Machulla, HJ [1 ]
机构：
[1] Univ Tubingen Hosp, Div Radiopharm, PET, Tubingen, Germany
来源：
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2002年 / 254卷 / 01期
关键词：
Electrodes - Fluorine compounds - Glassy carbon - Organic solvents;
D O I：
10.1023/A:1020825127344
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
For labeling reactions [F-18] fluoride has to be separated from [O-18] water and transferred into an organic solvent suitable for nucleophilic substitutions. An electrolytical method is described for depositing [F-18] fluoride on a vitreous carbon electrode and releasing it directly into CH3CN or DMSO. In the presence of Et(3)Nx3HF, [F-18] fluoride is almost quantitatively released into acetonitrile. When using n. c. a conditions, i. e., Et3N.HCl, desorption of the F-18 activity is almost 70% and 60% in acetonitrile and DMSO, respectively, already within 5 minutes.
引用
收藏
页码：29 / 31
页数：3
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