Electrochemical transfer of [18F]fluoride from [18O]water into organic solvents ready for labeling reactions

被引：0
|
作者：
G. Reischl
W. Ehrlichmann
H.-J. Machulla
机构：
[1] University Hospital,PET
来源：
Journal of Radioanalytical and Nuclear Chemistry | 2002年 / 254卷
关键词：
Physical Chemistry; DMSO; Inorganic Chemistry; Acetonitrile; Fluoride;
D O I：
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学科分类号：
摘要：
For labeling reactions [18F]fluoride has to be separated from [18O]water and transferred into an organic solvent suitable for nucleophilic substitutions. An electrolytical method is described for depositing [18F]fluoride on a vitreous carbon electrode and releasing it directly into CH3CN or DMSO. In the presence of Et3N×3HF, [18F]fluoride is almost quantitatively released into acetonitrile. When using n.c.a conditions, i.e., Et3N.HCl, desorption of the 18F activity is almost 70% and 60% in acetonitrile and DMSO, respectively, already within 5 minutes.
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页码：29 / 31
页数：2
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