Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation

被引：0

作者：

Jason Wray

Tüzer Kalkan

Sandra Gomez-Lopez

Dominik Eckardt

Andrew Cook

Rolf Kemler

Austin Smith

机构：

[1] University of Cambridge,Wellcome Trust Centre for Stem Cell Research & Department of Biochemistry

[2] Max-Planck Institute of Immunobiology,undefined

[3] World Wide Medicinal Chemistry,undefined

[4] Pfizer Ltd,undefined

[5] Present addresses: Cancer Institute,undefined

[6] University College London,undefined

[7] Paul O’Gorman Building,undefined

[8] 72 Huntley Street,undefined

[9] London WC1E 6BT,undefined

[10] UK (J.W.); Instituto de Fisiologı´a Celular,undefined

[11] División de Neurociencias,undefined

[12] UNAM,undefined

[13] Circuito Exterior s/n,undefined

[14] Ciudad Universitaria,undefined

[15] México,undefined

[16] DF 04510,undefined

[17] Mexico (S.G-L.); Miltenyi Biotec GmbH,undefined

[18] Friedrich-Ebert-Straße 68,undefined

[19] 51429 Bergisch Gladbach,undefined

[20] Germany (D.E.),undefined

来源：

Nature Cell Biology | 2011年 / 13卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The self-renewal of mouse embryonic stem cells is enhanced by inhibiting glycogen synthase kinase-3 (Gsk3). β-catenin is now found to be necessary for this effect through its interaction with Tcf3 to abrogate its repressive action for the expression of genes from the core pluripotency network.

引用

页码：838 / 845

页数：7

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