Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation

被引：0
|
作者：
Jason Wray
Tüzer Kalkan
Sandra Gomez-Lopez
Dominik Eckardt
Andrew Cook
Rolf Kemler
Austin Smith
机构：
[1] University of Cambridge,Wellcome Trust Centre for Stem Cell Research & Department of Biochemistry
[2] Max-Planck Institute of Immunobiology,undefined
[3] World Wide Medicinal Chemistry,undefined
[4] Pfizer Ltd,undefined
[5] Present addresses: Cancer Institute,undefined
[6] University College London,undefined
[7] Paul O’Gorman Building,undefined
[8] 72 Huntley Street,undefined
[9] London WC1E 6BT,undefined
[10] UK (J.W.); Instituto de Fisiologı´a Celular,undefined
[11] División de Neurociencias,undefined
[12] UNAM,undefined
[13] Circuito Exterior s/n,undefined
[14] Ciudad Universitaria,undefined
[15] México,undefined
[16] DF 04510,undefined
[17] Mexico (S.G-L.); Miltenyi Biotec GmbH,undefined
[18] Friedrich-Ebert-Straße 68,undefined
[19] 51429 Bergisch Gladbach,undefined
[20] Germany (D.E.),undefined
来源：
Nature Cell Biology | 2011年 / 13卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The self-renewal of mouse embryonic stem cells is enhanced by inhibiting glycogen synthase kinase-3 (Gsk3). β-catenin is now found to be necessary for this effect through its interaction with Tcf3 to abrogate its repressive action for the expression of genes from the core pluripotency network.
引用
收藏
页码：838 / 845
页数：7
相关论文
共 50 条
  • [31] The Antimalarial Effect of Curcumin Is Mediated by the Inhibition of Glycogen Synthase Kinase-3β
    Ali, Amatul Hamizah
    Sudi, Suhaini
    Basir, Rusliza
    Embi, Noor
    Sidek, Hasidah Mohd
    JOURNAL OF MEDICINAL FOOD, 2017, 20 (02) : 152 - 161
  • [32] Small Molecule Inhibition of Glycogen Synthase Kinase-3 in Cancer Immunotherapy
    Taylor, Alison
    Rudd, Christopher E.
    HUMAN CELL TRANSFORMATION: ADVANCES IN CELL MODELS FOR THE STUDY OF CANCER AND AGING, 2019, 1164 : 225 - 233
  • [33] Inhibition of glycogen synthase kinase-3 attenuates psychotomimetic effects of ketamine
    Chan, Ming-Huan
    Chiu, Pao-Hsiang
    Lin, Chia-Yu
    Chen, Hwei-Hsien
    SCHIZOPHRENIA RESEARCH, 2012, 136 (1-3) : 96 - 103
  • [34] In Vivo Evidence in the Brain for Lithium Inhibition of Glycogen Synthase Kinase-3
    Todd D Gould
    Guang Chen
    Husseini K Manji
    Neuropsychopharmacology, 2004, 29 : 32 - 38
  • [35] Glycogen Synthase Kinase-3β Inhibition Attenuates the Progression of Pulmonary Fibrosis
    Tucker, T. A.
    Jeffers, A.
    Ogunsakin, O. A.
    Owens, S.
    Fergis, A.
    Qin, W.
    Koenig, K.
    Idell, S.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
  • [36] Glycogen synthase kinase-3β inhibition blocks the effect of IL-1β on hippocampal neural precursor cell differentiation
    Green, H.
    Nolan, Y.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2010, 20 : S13 - S13
  • [37] Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis
    Ibrahim, Samar H.
    Akazawa, Yuko
    Cazanave, Sophie C.
    Bronk, Steven F.
    Elmi, Nafisa A.
    Werneburg, Nathan W.
    Billadeau, Daniel D.
    Gores, Gregory J.
    JOURNAL OF HEPATOLOGY, 2011, 54 (04) : 765 - 772
  • [38] Inhibition of Glycogen Synthase Kinase-3β Attenuates Glucocorticoid-Induced Suppression of Myogenic Differentiation In Vitro
    Ma, Zhenyu
    Zhong, Zhigang
    Zheng, Zhenyang
    Shi, Xing-Ming
    Zhang, Weixi
    PLOS ONE, 2014, 9 (08):
  • [39] Glycogen Synthase Kinase-3β (GSK-3β) Inhibition Attenuates Hepatocyte Lipoapoptosis
    Ibrahim, Samar H.
    Akazawa, Yuko
    Cazanave, Sophie
    Bronk, Steven F.
    Elmi, Nafisa
    Billadeau, Daniel D.
    Gores, Gregory J.
    GASTROENTEROLOGY, 2010, 138 (05) : S774 - S774
  • [40] Robust Self-Renewal of Rat Embryonic Stem Cells Requires Fine-Tuning of Glycogen Synthase Kinase-3 Inhibition
    Chen, Yaoyao
    Blair, Kathryn
    Smith, Austin
    STEM CELL REPORTS, 2013, 1 (03): : 209 - 217
12345