Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation

被引：0
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作者：
Jason Wray
Tüzer Kalkan
Sandra Gomez-Lopez
Dominik Eckardt
Andrew Cook
Rolf Kemler
Austin Smith
机构：
[1] University of Cambridge,Wellcome Trust Centre for Stem Cell Research & Department of Biochemistry
[2] Max-Planck Institute of Immunobiology,undefined
[3] World Wide Medicinal Chemistry,undefined
[4] Pfizer Ltd,undefined
[5] Present addresses: Cancer Institute,undefined
[6] University College London,undefined
[7] Paul O’Gorman Building,undefined
[8] 72 Huntley Street,undefined
[9] London WC1E 6BT,undefined
[10] UK (J.W.); Instituto de Fisiologı´a Celular,undefined
[11] División de Neurociencias,undefined
[12] UNAM,undefined
[13] Circuito Exterior s/n,undefined
[14] Ciudad Universitaria,undefined
[15] México,undefined
[16] DF 04510,undefined
[17] Mexico (S.G-L.); Miltenyi Biotec GmbH,undefined
[18] Friedrich-Ebert-Straße 68,undefined
[19] 51429 Bergisch Gladbach,undefined
[20] Germany (D.E.),undefined
来源：
Nature Cell Biology | 2011年 / 13卷
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摘要：
The self-renewal of mouse embryonic stem cells is enhanced by inhibiting glycogen synthase kinase-3 (Gsk3). β-catenin is now found to be necessary for this effect through its interaction with Tcf3 to abrogate its repressive action for the expression of genes from the core pluripotency network.
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页码：838 / 845
页数：7
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