Linkage, case-control association, and family-based association tests for complex disorders

被引：0
|
作者：
Brian K Suarez
Robert Culverhouse
Carol H Jin
Anthony Hinrichs
机构：
[1] Washington University School of Medicine,Department of Psychiatry
[2] Washington University School of Medicine,Department of Genetics
[3] Washington University School of Medicine,Department of Medicine
来源：
BMC Proceedings | / 1卷 / Suppl 1期
关键词：
Linkage Disequilibrium; Linkage Analysis; Association Analysis; Parental Genotype; Preferential Transmission;
D O I：
10.1186/1753-6561-1-S1-S43
中图分类号：
学科分类号：
摘要：
We carried out an analysis of the Genetic Analysis Workshop 15 simulated Problem 3 data. We restricted ourselves to the present/absent phenotype. Linkage analysis revealed a very strong signal on chromosome 6. Association analysis revealed additional susceptible loci located on chromosomes 11 and 18. The latter two signals were subsequently verified with linkage analysis – but only after 20 replicates were pooled. Analysis of linkage disequilibrium patterns, in concert with family-based association tests, led us to infer the presence of a second chromosome 6 locus located in the vicinity of single-nucleotide polymorphisms 160–162. These analyses were carried out without knowledge of the model used to generate the simulation.
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