A family-based and case-control association study of the NOTCH4 gene and schizophrenia

被引：44
|
作者：
Fan, JB
Tang, JX
Gu, NF
Feng, GY
Zou, FG
Xing, YL
Shi, JG
Zhao, SM
Zhu, SM
Ji, LP
Sun, WW
Zheng, YL
Liu, WQ
Breen, G
Clair, DS
He, L
机构：
[1] Shanghai Jiao Tong Univ, Bio X Life Sci Res Ctr, Shanghai 200030, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
[3] Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China
[4] Xian Inst Mental Hlth, Xian, Peoples R China
[5] Siping Inst Mental Hlth, Jilin, Peoples R China
[6] Shandong Univ, Dept Biol, Jinan 250100, Peoples R China
[7] Univ Aberdeen, Dept Mental Hlth, Sch Med, Aberdeen AB25 2ZD, Scotland
来源：
MOLECULAR PSYCHIATRY | 2002年 / 7卷 / 01期
关键词：
schizophrenia; Han; Chinese; family trios; Notch4; haplotype; TDT;
D O I：
10.1038/sj/mp/4000945
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recently a strong positive association between schizophrenia and Notch4 has been reported.(1) Both individual markers and haplotypes showed association with the disease, with five markers (three microsatellites and two SNPs) being tested. In order to test this finding we genotyped these markers in the Han Chinese population using a sample of 544 cases and 621 controls as well as >300 trios. Analysis of allele, genotype and haplotype frequencies in both samples showed no association between the markers and the disease. Our results would indicate that a significant role for the Notch4 gene in schizophrenia can be ruled out in the Han Chinese. However, similar studies are necessary in the Caucasian population as linkage disequilibrium arrangements and founder effects may differ between these two populations.
引用
收藏
页码：100 / 103
页数：4
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