Urinary metabolomic changes and microbiotic alterations in presenilin1/2 conditional double knockout mice

被引:0
|
作者
Jie Gao
Nian Zhou
Yongkang Wu
Mengna Lu
Qixue Wang
Chenyi Xia
Mingmei Zhou
Ying Xu
机构
[1] Shanghai University of Traditional Chinese Medicine,Department of Physiology, School of Basic Medicine
[2] Shanghai University of Traditional Chinese Medicine,Center for Chinese Medicine Therapy and Systems Biology, Institute of Interdisciplinary Integrative Medicine Research
[3] Affiliated Hospital of Nantong University,Department of Rehabilitation Medicine
[4] Shanghai University of Traditional Chinese Medicine,School of Pharmacy
关键词
Alzheimer’s disease; PS cDKO mice; Metabolomics; Gut microbiota; 16S rRNA sequencing;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [31] Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice
    Steven G Brodie
    Xiaoling Xu
    Wenhui Qiao
    Wen-Mei Li
    Liu Cao
    Chu-Xia Deng
    Oncogene, 2001, 20 : 7514 - 7523
  • [32] Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-κB pathway in presenilin 1/2 conditional double knockout mice
    Gao, Jie
    Wang, Lijun
    Zhao, Chenyi
    Wu, Yongkang
    Lu, Zhiyuan
    Gu, Yining
    Ba, Zongtao
    Wang, Xingyu
    Wang, Jian
    Xu, Ying
    JOURNAL OF LEUKOCYTE BIOLOGY, 2021, 110 (06) : 1005 - 1022
  • [33] Conditional Grsf1 knockout mice develop normally but show distinct transcriptomic and proteomic alterations in their testes
    Dumoulin, B.
    Lasse, M.
    Sajad, S.
    Kuehn, H.
    FEBS OPEN BIO, 2022, 12 : 283 - 283
  • [34] Increase of morphine withdrawal in mice lacking A2a receptors and no changes in CB1/A2a double knockout mice
    Berrendero, F
    Castañé, A
    Ledent, C
    Parmentier, M
    Maldonado, R
    Valverde, O
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 17 (02) : 315 - 324
  • [35] Increased Levels of NMDA Receptor NR2A Subunits at Pre- and Postsynaptic Sites of the Hippocampal CA1: An Early Response to Conditional Double Knockout of Presenilin 1 and 2
    Aoki, Chiye
    Lee, Joyce
    Nedelescu, Hermina
    Ahmed, Tunazzina
    Ho, Angela
    Shen, Jie
    JOURNAL OF COMPARATIVE NEUROLOGY, 2009, 517 (04) : 512 - 523
  • [36] Changes of Abeta levels in double knockout mice of Neprilysin and ABC-transporters lead to specific behavioral alterations
    Lange, C.
    Krohn, M.
    Hofrichter, J.
    Pahnke, J.
    ACTA NEUROPATHOLOGICA, 2009, 118 (03) : 449 - 449
  • [37] CRMP2 conditional knockout changes axonal function and ultrastructure of axons in mice corpus callosum
    Grycel, Katarzyna
    Larsen, Nick Y.
    Feng, Yinghang
    Qvortrup, Klaus
    Jensen, Poul Henning
    Fayyaz, Mishal
    Madsen, Malene G.
    Midtgaard, Jens
    Xu, Zhiheng
    Hasselholt, Stine
    Nyengaard, Jens R.
    MOLECULAR AND CELLULAR NEUROSCIENCE, 2023, 126
  • [38] Oligodendroglial conditional knockout of DARS2 results in white matter atrophy and neurobehavioral changes in mice
    Tiffany, C.
    Nemeth, C.
    Tomlinson, S.
    Murray, C.
    Johnston, M.
    Trifunovic, A.
    Fatemi, A.
    JOURNAL OF NEUROCHEMISTRY, 2017, 142 : 231 - 231
  • [39] Effect of allopurinol and febuxostat for urinary oxypurine excretion of Urat1-Uox double knockout mice
    Hosoyamada, Makoto
    Tomioka-Hara, Naoko
    Kobayashi, Chinatsu
    Tsurumi, Yu
    Sekine, Yuko
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2016, 130 (03) : S205 - S205
  • [40] Naive HIF-1a/ AhR keratinocyte-conditional double knockout mice resemble UVB-irradiated wildtype mice
    Fassbender, S.
    Schindler, J.
    Ramachandran, H.
    Nguyen, T.
    Majora, M.
    Haarmann-Stemmann, T.
    Esser, C.
    Rossi, A.
    Weighardt, H.
    Krutmann, J.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2023, 143 (05) : S199 - S199