Urinary metabolomic changes and microbiotic alterations in presenilin1/2 conditional double knockout mice

被引:0
|
作者
Jie Gao
Nian Zhou
Yongkang Wu
Mengna Lu
Qixue Wang
Chenyi Xia
Mingmei Zhou
Ying Xu
机构
[1] Shanghai University of Traditional Chinese Medicine,Department of Physiology, School of Basic Medicine
[2] Shanghai University of Traditional Chinese Medicine,Center for Chinese Medicine Therapy and Systems Biology, Institute of Interdisciplinary Integrative Medicine Research
[3] Affiliated Hospital of Nantong University,Department of Rehabilitation Medicine
[4] Shanghai University of Traditional Chinese Medicine,School of Pharmacy
关键词
Alzheimer’s disease; PS cDKO mice; Metabolomics; Gut microbiota; 16S rRNA sequencing;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] APP processing and synaptic plasticity in presenilin-1 conditional knockout mice
    Yu, HK
    Saura, CA
    Choi, SY
    Sun, LD
    Yang, XD
    Handler, M
    Kawarabayashi, T
    Younkin, L
    Fedeles, B
    Wilson, MA
    Younkin, S
    Kandel, ER
    Kirkwood, A
    Shen, J
    NEURON, 2001, 31 (05) : 713 - 726
  • [22] Alpha7 nicotinic acetylcholine receptor agonist PHA-543613 improves memory deficits in presenilin 1 and presenilin 2 conditional double knockout mice
    Lv, Junyan
    Duan, Yanhong
    Wang, Xinhe
    Wu, Hao
    Chen, Jinnan
    Zhang, Wei
    Ke, Shaofa
    Wang, Feng
    Ni, Hong
    Cao, Xiaohua
    EXPERIMENTAL NEUROLOGY, 2023, 359
  • [23] Increased Inflammatory Response Both in Brain and in Periphery in Presenilin 1 and Presenilin 2 Conditional Double Knock-Out Mice
    Jiang, Xu
    Zhang, Dongli
    Shi, Jianting
    Chen, Yiqun
    Zhang, Ping
    Mei, Bing
    JOURNAL OF ALZHEIMERS DISEASE, 2009, 18 (03) : 515 - 523
  • [24] Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice
    Wu, Pu
    Shen, Qian
    Dong, Suzhen
    Xu, Zhiliang
    Tsien, Joe Z.
    Hu, Yinghe
    NEUROBIOLOGY OF AGING, 2008, 29 (10) : 1502 - 1511
  • [25] Elevation of Aβ peptide 2-42 sporadic and familial Alzheimer's disease and its generation in presenilin1 knockout cells
    Wiltfang, J
    Esselmann, H
    Ruether, E
    Cupers, P
    Annaert, W
    De Strooper, B
    Neumann, M
    Kretzschmar, H
    Beyermann, M
    Schleuder, D
    John, H
    Kornhuber, J
    Saftig, P
    NEUROBIOLOGY OF AGING, 2002, 23 (01) : S217 - S217
  • [26] Age-related changes of the lens in Tropomyosin 1 conditional knockout mice
    Shibata, Teppei
    Shibata, Shinsuke
    Singh, Dhirendra P.
    Kiyokawa, Etsuko
    Ikawa, Masahito
    Sasaki, Hiroshi
    Kubo, Eri
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2019, 60 (09)
  • [27] Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2
    Feng, RB
    Wang, HM
    Wang, JL
    Shrom, D
    Zeng, XM
    Tsien, JZ
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (21) : 8162 - 8167
  • [28] Anxiety in BACE 1 & 2 double knockout mice
    Harper, A
    Morrison, A
    Austin, A
    Chapman, H
    Quinn, L
    Barber, S
    Dingwall, C
    JOURNAL OF PSYCHOPHARMACOLOGY, 2004, 18 (03) : A22 - A22
  • [29] Inflammatory changes in barrier deficient corneas in conditional Notch1 knockout mice
    Djalilian, Ali R.
    Movahedan, Asadolah
    Afshar, Neda
    Eslani, Medi
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (13)
  • [30] Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice
    Brodie, SG
    Xu, XL
    Qiao, WH
    Li, WM
    Cao, L
    Deng, CX
    ONCOGENE, 2001, 20 (51) : 7514 - 7523