Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters

被引：0
|
作者：
Yun Chen
Athma A Pai
Jan Herudek
Michal Lubas
Nicola Meola
Aino I Järvelin
Robin Andersson
Vicent Pelechano
Lars M Steinmetz
Torben Heick Jensen
Albin Sandelin
机构：
[1] The Bioinformatics Centre,Department of Biology
[2] University of Copenhagen,Department of Biology
[3] Biotech Research and Innovation Centre,Department of Molecular Biology and Genetics
[4] University of Copenhagen,Department of Genetics
[5] Massachusetts Institute of Technology,undefined
[6] Centre for mRNP Biogenesis and Metabolism,undefined
[7] Aarhus University,undefined
[8] European Molecular Biology Laboratory,undefined
[9] Genome Biology Unit,undefined
[10] Stanford Genome Technology Center,undefined
[11] Stanford University School of Medicine,undefined
[12] Present addresses: Department of Biochemistry,undefined
[13] Oxford University,undefined
[14] Oxford,undefined
[15] United Kingdom (A.I.J.) and SciLifeLab,undefined
[16] Department of Microbiology,undefined
[17] Tumor and Cell Biology,undefined
[18] Karolinska Institutet,undefined
[19] Stockholm,undefined
[20] Sweden (V.P.).,undefined
来源：
Nature Genetics | 2016年 / 48卷
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摘要：
Yun Chen, Albin Sandelin, Torben Heick Jensen and colleagues describe general rules governing the expression of reverse-oriented promoter upstream transcripts (PROMPTs) based on the orientation and proximity of promoter pairs. They characterize how the distance between promoters affects the expression of PROMPTs and the usage of alternate mRNA transcription start sites.
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页码：984 / 994
页数：10
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