Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters

被引：0

作者：

Yun Chen

Athma A Pai

Jan Herudek

Michal Lubas

Nicola Meola

Aino I Järvelin

Robin Andersson

Vicent Pelechano

Lars M Steinmetz

Torben Heick Jensen

Albin Sandelin

机构：

[1] The Bioinformatics Centre,Department of Biology

[2] University of Copenhagen,Department of Biology

[3] Biotech Research and Innovation Centre,Department of Molecular Biology and Genetics

[4] University of Copenhagen,Department of Genetics

[5] Massachusetts Institute of Technology,undefined

[6] Centre for mRNP Biogenesis and Metabolism,undefined

[7] Aarhus University,undefined

[8] European Molecular Biology Laboratory,undefined

[9] Genome Biology Unit,undefined

[10] Stanford Genome Technology Center,undefined

[11] Stanford University School of Medicine,undefined

[12] Present addresses: Department of Biochemistry,undefined

[13] Oxford University,undefined

[14] Oxford,undefined

[15] United Kingdom (A.I.J.) and SciLifeLab,undefined

[16] Department of Microbiology,undefined

[17] Tumor and Cell Biology,undefined

[18] Karolinska Institutet,undefined

[19] Stockholm,undefined

[20] Sweden (V.P.).,undefined

来源：

Nature Genetics | 2016年 / 48卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Yun Chen, Albin Sandelin, Torben Heick Jensen and colleagues describe general rules governing the expression of reverse-oriented promoter upstream transcripts (PROMPTs) based on the orientation and proximity of promoter pairs. They characterize how the distance between promoters affects the expression of PROMPTs and the usage of alternate mRNA transcription start sites.

引用

页码：984 / 994

页数：10

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