The synchronized catalytic dance of CRISPR-Cas9

被引：0
|
作者：
Aakash Saha
Chinmai Pindi
Giulia Palermo
机构：
[1] The University of California,Department of Bioengineering
[2] The University of California,Department of Chemistry
来源：
Nature Catalysis | 2023年 / 6卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
CRISPR-Cas9 is a major gene-editing tool that has attracted tremendous interdisciplinary efforts to ameliorate precise genome manipulation. Now, the pivotal structural features behind concerted double-stranded DNA cleavages by the Cas9 endonuclease have been captured through cryo-electron microscopy, laying the groundwork for improved Cas9 engineering.
引用
收藏
页码：870 / 872
页数：2
相关论文
共 50 条
  • [31] Introduction to CRISPR-Cas9 Gene Editing
    Mason, J. M.
    BIRTH DEFECTS RESEARCH, 2020, 112 (11): : 809 - 809
  • [32] Progress of delivery methods for CRISPR-Cas9
    Yang, Wu
    Yan, Jiaqi
    Zhuang, Pengzhen
    Ding, Tao
    Chen, Yu
    Zhang, Yu
    Zhang, Hongbo
    Cui, Wenguo
    EXPERT OPINION ON DRUG DELIVERY, 2022, 19 (08) : 913 - 926
  • [33] Chemical Control of a CRISPR-Cas9 Acetyltransferase
    Shrimp, Jonathan H.
    Grose, Carissa
    Widmeyer, Stephanie R. T.
    Thorpe, Abigail L.
    Jadhav, Ajit
    Meier, Jordan L.
    ACS CHEMICAL BIOLOGY, 2018, 13 (02) : 455 - 460
  • [34] CRISPR-Cas9 can cause chromothripsis
    Urnov, Fyodor D.
    NATURE GENETICS, 2021, 53 (06) : 768 - 769
  • [35] CRISPR-Cas9 Dissection of Heparan Sulfate
    Weiss, Ryan J.
    Spahn, Philipp N.
    Lewis, Nathan E.
    Esko, Jeffrey D.
    GLYCOBIOLOGY, 2017, 27 (12) : 1211 - 1211
  • [36] CRISPR-Cas9 for treating hereditary diseases
    Mani, Indra
    REPROGRAMMING THE GENOME: CRISPR-CAS-BASED HUMAN DISEASE THERAPY, 2021, 181 : 165 - 183
  • [37] CRISPR-Cas9 Applications in Cardiovascular Disease
    Khouzam, John Paul S.
    Tivakaran, Vijai S.
    CURRENT PROBLEMS IN CARDIOLOGY, 2021, 46 (03)
  • [38] Inhibition of CRISPR-Cas9 with Bacteriophage Proteins
    Rauch, Benjamin J.
    Silvis, Melanie R.
    Hultquist, Judd F.
    Waters, Christopher S.
    McGregor, Michael J.
    Krogan, Nevan J.
    Bondy-Denomy, Joseph
    CELL, 2017, 168 (1-2) : 150 - +
  • [39] CRISPR-Cas9 dissection of heparan sulfate
    Weiss, Ryan J.
    Spahn, Philipp N.
    Lewis, Nathan E.
    Esko, Jeffrey D.
    CANCER RESEARCH, 2017, 77
  • [40] Biomaterials as vectors for the delivery of CRISPR-Cas9
    Eoh, Joon
    Gu, Luo
    BIOMATERIALS SCIENCE, 2019, 7 (04) : 1240 - 1261
12345