Comparison of optimization methods for fed-batch cultures of hybridoma cells

被引：0
|
作者：
J. A. Roubos
C. D. de Gooijer
G. van Straten
A. J. B. van Boxtel
机构：
[1] Wageningen Agricultural University,
[2] Department of Agricultural Engineering and Physics,undefined
[3] Bomenweg 4,undefined
[4] 6703 HD Wageningen,undefined
[5] the Netherlands,undefined
来源：
Bioprocess Engineering | 1997年 / 17卷
关键词：
Dynamic Programming; Gradient Method; Computational Effort; Suitable Method; Programming Approach;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Two methods for the calculation of optimal trajectories for the input variables of a fed-batch culture of hybridoma cells are compared. It pointed out that a gradient method based on Pontryagins' minimum principle based yields a significant better performance with respect to computational effort and the calculated minimum than a dynamic programming approach which has been presented in a previous paper [1] as the most suitable method.
引用
收藏
页码：99 / 102
页数：3
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