Benzodiazepine-Like Substances and Hepatic EncephalopathyImplications for Treatment

被引：0
|
作者：
Jill A. Cossar
Peter C. Hayes
Ronan E. O’Carroll
机构：
[1] Edinburgh Royal Infirmary,Department of Medicine
[2] University of Stirling,Psychology Department
来源：
CNS Drugs | 1997年 / 8卷
关键词：
Hepatic Encephalopathy; Flumazenil; Fulminant Hepatic Failure; Gamma Amino Butyric Acid; Visual Evoke Response;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Hepatic encephalopathy is a neuropsychiatric syndrome that can complicate acute and chronic liver disease. Recent research has focused on the role benzodiazepine-like substances play in the pathogenesis of this disorder. It has been proposed that potentiation of the action of the neuroinhibitory transmitter γr-aminobutyric acid (GABA) through the binding of endogenous benzodiazepine agonists to the benzodiazepine receptor binding site accounts for the clinical and biochemical features of this condition.
引用
收藏
页码：91 / 101
页数：10
相关论文
共 50 条
  • [31] DEMONSTRATION OF 2 NEW ENDOGENOUS BENZODIAZEPINE-LIKE COMPOUNDS FROM BRAIN
    MARANGOS, PJ
    CLARK, R
    MARTINO, AM
    PAUL, SM
    SKOLNICK, P
    PSYCHIATRY RESEARCH, 1979, 1 (02) : 121 - 130
  • [32] Comparison of benzodiazepine-like compounds using topological analysis and genetic algorithms
    Meurice, N
    Leherte, L
    Vercauteren, DP
    SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 1998, 8 (3-4) : 195 - +
  • [33] Endotoxinemia and benzodiazepine-like substances in compensated cirrhotic patients: a randomized study comparing the effect of rifaximine alone and in association with a symbiotic preparation
    Lighthouse, J
    Naito, Y
    Helmy, A
    Hotten, P
    Fuji, H
    Min, CH
    Yoshioka, M
    Marotta, F
    HEPATOLOGY RESEARCH, 2004, 28 (03) : 155 - 160
  • [34] Quantitative analysis of 33 benzodiazepines, metabolites and benzodiazepine-like substances in whole blood by liquid chromatography-(tandem) mass spectrometry
    Smink, BE
    Brandsma, JE
    Dijkhuizen, A
    Lusthof, KJ
    de Gier, JJ
    Egberts, ACG
    Uges, DRA
    JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2004, 811 (01): : 13 - 20
  • [35] IN-VIVO FORMATION OF BENZODIAZEPINE-LIKE MOLECULES IN RAT-BRAIN
    MEDINA, JH
    WOLFMAN, C
    DESTEIN, ML
    WASOWSKI, C
    DEBLAS, A
    PALADINI, AC
    JOURNAL OF NEUROCHEMISTRY, 1993, 61 : S77 - S77
  • [36] BENZODIAZEPINE-LIKE MOLECULES, AS WELL AS OTHER LIGANDS FOR THE BRAIN BENZODIAZEPINE RECEPTORS, ARE RELATIVELY COMMON CONSTITUENTS OF PLANTS
    MEDINA, JH
    PENA, C
    DESTEIN, ML
    WOLFMAN, C
    PALADINI, AC
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (02) : 547 - 553
  • [37] LEVELS OF ENDOGENOUS BENZODIAZEPINE-LIKE COMPOUNDS IN SERUM OF LIVER-CIRRHOSIS PATIENTS WITH AND WITHOUT ENCEPHALOPATHY AND IN FULMINANT HEPATIC-FAILURE
    ZENEROLI, ML
    VENTURINI, I
    AVALLONE, R
    ARDIZZONE, G
    DEMARTINI, M
    PORTELLA, G
    BARALDI, M
    HEPATOLOGY, 1994, 19 (04) : I143 - I143
  • [38] Changes in endogenous benzodiazepine-like compound levels during the course of fulminant hepatic failure: potential effects of decreased renal function
    Zeneroli, ML
    Venturini, I
    Avallone, R
    Farina, F
    Miglioli, L
    Cosenza, R
    Amedei, R
    Ardizzone, G
    Centanaro, M
    Arrigo, A
    Baraldi, M
    ITALIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1997, 29 (05): : 456 - 458
  • [39] Lack of benzodiazepine-like effects of cannabinoid CB1 agonists in monkeys
    Paronis, CA
    Delatte, MS
    Zakarian, A
    FASEB JOURNAL, 2005, 19 (05): : A1074 - A1074
  • [40] PLASMA ENDOGENOUS BENZODIAZEPINE-LIKE ACTIVITY IN SLEEP DISORDERS WITH EXCESSIVE DAYTIME SLEEPINESS
    MONTAGNA, P
    SFORZA, E
    TINUPER, P
    PROVINI, F
    PLAZZI, G
    CORTELLI, P
    SCHOCH, P
    ROTHSTEIN, JD
    LUGARESI, E
    NEUROLOGY, 1995, 45 (09) : 1783 - 1783
12345