Stem cell therapy for central nervous system demyelinating disease

被引：14
|
作者：
Manganas L.N. [1 ]
Maletic-Savatic M. [1 ]
机构：
[1] Department of Neurology, Stony Brook University, Stony Brook
来源：
Current Neurology and Neuroscience Reports | 2005年 / 5卷 / 3期
关键词：
Multiple Sclerosis; Experimental Autoimmune Encephalomyelitis; Neural Stem Cell; Stem Cell Therapy; Bone Marrow Stem Cell;
D O I：
10.1007/s11910-005-0050-z
中图分类号：
学科分类号：
摘要：
Recent advances in cell-based therapies for demyelinating central nervous system diseases have demonstrated the ability to restore damaged neuronal architecture and function. Demyelinated axons in patients with multiple sclerosis can spontaneously remyelinate over time; however, the rate and extent at which remyelination occurs is inadequate for complete recovery. Previous attempts aimed at regenerating myelin-forming cells have been successful but limited by the multifocal nature of the lesions and the inability to produce large numbers of myelin-producing cells in culture. Stem cell-based therapy can overcome these limitations to some extent and may prove useful in the future treatment of demyelinating diseases. Copyright © 2005 by Current Science Inc.
引用
收藏
页码：225 / 231
页数：6
相关论文
共 50 条
  • [31] Primary Central Nervous System Cytotoxic T-cell Lymphoma Mimicking Demyelinating Disease
    Kato, Yuji
    Hayashi, Takeshi
    Kawai-Masaoka, Akiko
    Ichimura, Takaya
    Sasaki, Atsushi
    Uchino, Akira
    Nagamine, Yuito
    Tanahashi, Norio
    INTERNAL MEDICINE, 2014, 53 (11) : 1197 - 1200
  • [32] Multiphasic demyelinating disease involving central and peripheral nervous system in a child
    Mariotti, P
    Batocchi, AP
    Colosimo, C
    Lo Monaco, M
    Caggiula, M
    Colitto, F
    Tonali, PA
    Guzzetta, F
    NEUROLOGY, 2003, 60 (02) : 348 - 349
  • [33] Macrophagic myofasciitis in patients with demyelinating central nervous system disease.
    Cherin, P
    Authier, FJ
    Laforet, P
    Abdelmoumni, A
    Creange, A
    Bonnotte, B
    Ranoux, D
    Maisonoble, T
    Degos, JD
    Gherardi, RK
    Herson, S
    ARTHRITIS AND RHEUMATISM, 1999, 42 (09): : S156 - S156
  • [34] Central Nervous System Immune-mediated Demyelinating Disease after Allogeneic Hematopoietic Stem Cell Transplantation (A case of central nervous system graft-versus-host disease mimicking multiple sclerosis after allogeneic hematopoietic stem cell transplantation)
    Oh, Seung-Tae
    Ahn, Jung Woo
    Oh, Seong-il
    MULTIPLE SCLEROSIS JOURNAL, 2020, 26 (09) : NP97 - NP97
  • [35] Monophasic demyelinating disease of the central nervous system associated with Hepatitis A infection
    Quaranta, Loreta
    Batocchi, Anna Paola
    Sabatelli, Mario
    Nociti, Viviana
    Tartaglione, Tommaso
    Cuonzo, Francesca
    Tonali, Pietro Attilio
    JOURNAL OF NEUROLOGY, 2006, 253 (07) : 944 - 945
  • [36] Demyelinating Disease of the Central Nervous System Concurrent With COVID-19
    Karsidag, Sibel
    Sahin, Sevki
    Ates, Miruna F.
    Cinar, Nilgun
    Kendirli, Sude
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2021, 13 (08)
  • [37] Mechanisms of immunopathology in murine models of central nervous system demyelinating disease
    Ercolini, Anne M.
    Miller, Stephen D.
    JOURNAL OF IMMUNOLOGY, 2006, 176 (06): : 3293 - 3298
  • [38] Central nervous system Cryptococcoma mimicking demyelinating disease: a case report
    Wei, Jie
    Li, Xiang-Yu
    Zhang, Yue
    BMC NEUROLOGY, 2020, 20 (01)
  • [39] Central nervous system Cryptococcoma mimicking demyelinating disease: a case report
    Jie Wei
    Xiang-Yu Li
    Yue Zhang
    BMC Neurology, 20
  • [40] Stem cell biology of the central nervous system
    Okano, H
    JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 69 (06) : 698 - 707
12345