Stem cell therapy for central nervous system demyelinating disease

被引：14
|
作者：
Manganas L.N. [1 ]
Maletic-Savatic M. [1 ]
机构：
[1] Department of Neurology, Stony Brook University, Stony Brook
来源：
Current Neurology and Neuroscience Reports | 2005年 / 5卷 / 3期
关键词：
Multiple Sclerosis; Experimental Autoimmune Encephalomyelitis; Neural Stem Cell; Stem Cell Therapy; Bone Marrow Stem Cell;
D O I：
10.1007/s11910-005-0050-z
中图分类号：
学科分类号：
摘要：
Recent advances in cell-based therapies for demyelinating central nervous system diseases have demonstrated the ability to restore damaged neuronal architecture and function. Demyelinated axons in patients with multiple sclerosis can spontaneously remyelinate over time; however, the rate and extent at which remyelination occurs is inadequate for complete recovery. Previous attempts aimed at regenerating myelin-forming cells have been successful but limited by the multifocal nature of the lesions and the inability to produce large numbers of myelin-producing cells in culture. Stem cell-based therapy can overcome these limitations to some extent and may prove useful in the future treatment of demyelinating diseases. Copyright © 2005 by Current Science Inc.
引用
收藏
页码：225 / 231
页数：6
相关论文
共 50 条
  • [21] Helicobacter pylori infection and demyelinating disease of the central nervous system
    Kira, Jun-ichi
    Isobe, Noriko
    JOURNAL OF NEUROIMMUNOLOGY, 2019, 329 : 14 - 19
  • [22] Relapsing demyelinating disease of both central and peripheral nervous system
    Zephir, H
    Stojkovic, T
    de Seze, J
    Outteryck, O
    Daems, C
    Vermersch, P
    NEUROLOGY, 2006, 66 (05) : A226 - A226
  • [23] AdalimumabInflammatory demyelinating disease in the central nervous system: case report
    Reactions Weekly, 2024, 2036 (1) : 21 - 21
  • [24] β7 integrins contribute to demyelinating disease of the central nervous system
    Kanwar, JR
    Harrison, JEB
    Wang, DM
    Leung, E
    Mueller, W
    Wagner, N
    Krissansen, GW
    JOURNAL OF NEUROIMMUNOLOGY, 2000, 103 (02) : 146 - 152
  • [25] Stem and progenitor cell–based therapy of the human central nervous system
    Steve Goldman
    Nature Biotechnology, 2005, 23 : 862 - 871
  • [26] Stem Cell Therapy for the Central Nervous System in Lysosomal Storage Diseases
    Siddiqi, Faez
    Wolfe, John H.
    HUMAN GENE THERAPY, 2016, 27 (10) : 749 - 757
  • [27] Stem cell-based therapy in central nervous system diseases
    Paczkowska, Edyta
    Dabkowska, Elzbieta
    Nowacki, Przemyslaw
    Machalinski, Boguslaw
    NEUROLOGIA I NEUROCHIRURGIA POLSKA, 2009, 43 (06) : 550 - 558
  • [28] Central nervous system Listeria monocytogenes infection mimicking central nervous system idiopathic inflammatory demyelinating disease
    Xu, Rui
    Bai, Yang
    Duan, Chunmei
    Zhao, Shifu
    Chen, Xiaoyan
    Yang, Qingwu
    INFECTION AND DRUG RESISTANCE, 2019, 12 : 255 - 259
  • [29] CYTOMEGALOVIRUS CENTRAL NERVOUS SYSTEM DISEASE IN STEM CELL TRANSPLANT RECIPIENTS
    Reddy, S. M.
    Winston, D. J.
    Territo, M. C.
    Schiller, G. J.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2010, 58 (01) : 131 - 131
  • [30] Secondary Central Nervous System Diffuse Large B Cell Lymphoma Mimicking Demyelinating Disease
    Park, M. S.
    Kim, D. H.
    Yun, D. J.
    MULTIPLE SCLEROSIS JOURNAL, 2012, 18 (04) : 547 - 547
12345