Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors

被引：0

作者：

Bertram Kjerulff

Joseph Dowsett

Rikke Louise Jacobsen

Josephine Gladov

Margit Hørup Larsen

Agnete Troen Lundgaard

Karina Banasik

David Westergaard

Susan Mikkelsen

Khoa Manh Dinh

Lotte Hindhede

Kathrine Agergård Kaspersen

Michael Schwinn

Anders Juul

Betina Poulsen

Birgitte Lindegaard

Carsten Bøcker Pedersen

Clive Eric Sabel

Henning Bundgaard

Henriette Svarre Nielsen

Janne Amstrup Møller

Jens Kjærgaard Boldsen

Kristoffer Sølvsten Burgdorf

Lars Vedel Kessing

Linda Jenny Handgaard

Lise Wegner Thørner

Maria Didriksen

Mette Nyegaard

Niels Grarup

Niels Ødum

Pär I. Johansson

Poul Jennum

Ruth Frikke-Schmidt

Sanne Schou Berger

Søren Brunak

Søren Jacobsen

Thomas Folkmann Hansen

Tine Kirkeskov Lundquist

Torben Hansen

Torben Lykke Sørensen

Torben Sigsgaard

Kaspar René Nielsen

Mie Topholm Bruun

Henrik Hjalgrim

Henrik Ullum

Klaus Rostgaard

Erik Sørensen

Ole Birger Pedersen

Sisse Rye Ostrowski

Christian Erikstrup

机构：

[1] Aarhus University Hospital,Department of Clinical Immunology

[2] Aarhus University,Department of Clinical Medicine

[3] Aarhus University,BERTHA Big Data Centre for Environment and Health

[4] Copenhagen University Hospital,Department of Clinical Immunology

[5] Rigshospitalet,Translational Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences

[6] University of Copenhagen,Department of Clinical Medicine, Faculty of Health and Medical Sciences

[7] University of Copenhagen,Department of Growth and Reproduction

[8] Copenhagen University Hospital — Rigshospitalet,International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC)

[9] Rigshospitalet,Department of Pulmonary and Infectious Diseases

[10] University of Copenhagen,National Centre for Register

[11] Copenhagen University Hospital—North Zealand,based Research

[12] Aarhus BSS,Department of Public Health

[13] Aarhus University,School of Geography, Earth and Environmental Sciences

[14] Aarhus University,The Heart Center, Rigshospitalet

[15] University of Plymouth,Recurrent Pregnancy Loss Unit, Capital Region

[16] Copenhagen University Hospital,Department of Obstetrics and Gynecology

[17] Copenhagen University Hospitals,Copenhagen Affective Disorder Research Center (CADIC)

[18] Hvidovre and Rigshospitalet,Department of Health Science and Technology

[19] Copenhagen University Hospital,Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences

[20] Psychiatric Center Copenhagen,LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology

[21] Aalborg University,Danish Center for Sleep Medicine

[22] University of Copenhagen,Department of Clinical Biochemistry

[23] University of Copenhagen,Centre for Diagnostics, DTU Health Technology

[24] Department of Clinical Neurophysiology,Copenhagen Lupus and Vasculitis Clinic

[25] Rigshospitalet,Danish Headache Center and Danish Multiple Sclerosis Center

[26] Copenhagen University Hospital—Rigshospitalet,Clinical Eye Research Division, Department of Ophthalmology

[27] Technical University of Denmark,Department of Clinical Immunology

[28] Center for Rheumatology and Spine Diseases,Department of Clinical Immunology

[29] Rigshospitalet,Department of Epidemiology Research

[30] Copenhagen University Hospital,Danish Cancer Society Research Center

[31] Rigshospitalet Glostrup,Department of Hematology

[32] Zealand University,Department of Clinical Immunology

[33] Hospital,undefined

[34] Aalborg University Hospital,undefined

[35] Odense University Hospital,undefined

[36] Statens Serum Institut,undefined

[37] Danish Cancer Society,undefined

[38] Copenhagen University Hospital,undefined

[39] Statens Serum Institut,undefined

[40] Zealand University Hospital,undefined

来源：

Communications Medicine | / 4卷

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摘要：

Blood-based biomarkers are circulating molecules that can help to indicate health or disease. Biomarker levels may vary depending on demographic and lifestyle factors such as age, sex, smoking status, and body mass index. Here, we examine the effects of these demographic and lifestyle factors on levels of biomarkers related to activation of the immune system and cardiovascular stress. Measurements of 47 different proteins were performed on blood samples from nearly 10,000 healthy Danish blood donors. Measurement data were linked with questionnaire data to assess effects of lifestyle. We found that immune activation and vascular stress generally increased with age, BMI, and smoking. As these measurements are from healthy blood donors they can serve as a reference for expectable effects and inflammation levels in healthy individuals. Knowledge about the healthy state is important for understanding disease progression and optimizing care.

引用

共 39 条

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