Host tissue determinants of tumour immunity

被引:0
|
作者
Hélène Salmon
Romain Remark
Sacha Gnjatic
Miriam Merad
机构
[1] Icahn School of Medicine at Mount Sinai,Department of Oncological Sciences
[2] Icahn School of Medicine at Mount Sinai,Precision Immunology Institute and Tisch Cancer Institute
[3] INSERM U932,Department of Hematology and Oncology
[4] Institut Curie,undefined
[5] Innate Pharma,undefined
[6] Icahn School of Medicine at Mount Sinai,undefined
来源
Nature Reviews Cancer | 2019年 / 19卷
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摘要
Although common evolutionary principles drive the growth of cancer cells regardless of the tissue of origin, the microenvironment in which tumours arise substantially differs across various organ sites. Recent studies have established that, in addition to cell-intrinsic effects, tumour growth regulation also depends on local cues driven by tissue environmental factors. In this Review, we discuss how tissue-specific determinants might influence tumour development and argue that unravelling the tissue-specific contribution to tumour immunity should help the development of precise immunotherapeutic strategies for patients with cancer.
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页码:215 / 227
页数:12
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