Genetic determinants of host immunity against human rhinovirus infections

被引：11

作者：

Lamborn, Ian T. ^{[1
,2
]}

Su, Helen C. ^{[1
]}

机构：

[1] NIAID, Human Immunol Dis Sect, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[2] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06510 USA

来源：

HUMAN GENETICS | 2020年 / 139卷 / 6-7期

基金：

美国国家卫生研究院;

关键词：

SINGLE-STRANDED RNA; PYOGENIC BACTERIAL-INFECTIONS; HERPES-SIMPLEX ENCEPHALITIS; TOLL-LIKE RECEPTOR-3; FAMILY-MEMBER; RIG-I; ANTIVIRAL RESPONSES; VIRUS ENCEPHALITIS; TLR3; DEFICIENCY; KAPPA-B;

D O I：

10.1007/s00439-020-02137-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Human rhinoviruses (RV) are a frequent cause of respiratory tract infections with substantial morbidity and mortality in some patients. Nevertheless, the genetic basis of susceptibility to RV in humans has been relatively understudied. Experimental infections of mice and in vitro infections of human cells have indicated that various pathogen recognition receptors (TLRs, RIG-I, and MDA5) regulate innate immune responses to RV. However, deficiency of MDA5 is the only one among these so far uncovered that confers RV susceptibility in humans. Other work has shown increased RV susceptibility in patients with a polymorphism in CDHR3 that encodes the cellular receptor for RV-C entry. Here, we provide a comprehensive review of the genetic determinants of human RV susceptibility in the context of what is known about RV biology.

引用

页码：949 / 959

页数：11

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