Genetic determinants of host immunity against human rhinovirus infections

被引：11

作者：

Lamborn, Ian T. ^{[1
,2
]}

Su, Helen C. ^{[1
]}

机构：

[1] NIAID, Human Immunol Dis Sect, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[2] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06510 USA

来源：

HUMAN GENETICS | 2020年 / 139卷 / 6-7期

基金：

美国国家卫生研究院;

关键词：

SINGLE-STRANDED RNA; PYOGENIC BACTERIAL-INFECTIONS; HERPES-SIMPLEX ENCEPHALITIS; TOLL-LIKE RECEPTOR-3; FAMILY-MEMBER; RIG-I; ANTIVIRAL RESPONSES; VIRUS ENCEPHALITIS; TLR3; DEFICIENCY; KAPPA-B;

D O I：

10.1007/s00439-020-02137-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Human rhinoviruses (RV) are a frequent cause of respiratory tract infections with substantial morbidity and mortality in some patients. Nevertheless, the genetic basis of susceptibility to RV in humans has been relatively understudied. Experimental infections of mice and in vitro infections of human cells have indicated that various pathogen recognition receptors (TLRs, RIG-I, and MDA5) regulate innate immune responses to RV. However, deficiency of MDA5 is the only one among these so far uncovered that confers RV susceptibility in humans. Other work has shown increased RV susceptibility in patients with a polymorphism in CDHR3 that encodes the cellular receptor for RV-C entry. Here, we provide a comprehensive review of the genetic determinants of human RV susceptibility in the context of what is known about RV biology.

引用

页码：949 / 959

页数：11

共 50 条

[41] IMMUNOGENETIC ASPECTS OF NATURAL HUMAN IMMUNITY AGAINST INFECTIONS WITH GROUP-A STREPTOCOCCI
LAUDIEN, D
BRAUN, D
RIESEN, W
SCHUNTER, F
WERNET, P
[J]. ZEITSCHRIFT FUR IMMUNITATSFORSCHUNG-IMMUNOBIOLOGY, 1979, 156 (03): : 230 - 230
[42] A novel rhinovirus mRNA vaccine induces humoral and cellular immunity, providing protection against heterotypic rhinovirus infection
Pyle, Chloe Julia
Patel, Neeta D.
Hamblin, Paul
Butt, Richard
Edwards, Michael R.
Shaw, Stephen
Johnston, Sebastian L.
[J]. EUROPEAN RESPIRATORY JOURNAL, 2023, 62
[43] ROLE OF HOST GENETIC DETERMINANTS OF INNATE IMMUNITY IN MOTHER-TO-CHILD TRANSMISSION OF HIV-1
Ricci, E.
Malacrida, S.
Zanchetta, M.
Mosconi, I.
Montagna, M.
Giaquinto, C.
De Rossi, A.
[J]. INFECTION, 2009, 37 : 98 - 98
[44] Host Genetic Determinants of Human Immunodeficiency Virus Infection and Disease Progression in Children
Kumud K Singh
Stephen A Spector
[J]. Pediatric Research, 2009, 65 : 55 - 63
[45] Host Genetic Determinants of Human Immunodeficiency Virus Infection and Disease Progression in Children
Singh, Kumud K.
Spector, Stephen A.
[J]. PEDIATRIC RESEARCH, 2009, 65 (05) : 55R - 63R
[46] Genetic determinants for cfxA expression in Bacteroides strains isolated from human infections
Garcia, Nuria
Gutierrez, Gloria
Lorenzo, Maria
Garcia, Jose E.
Piriz, Segundo
Quesada, Alberto
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 62 (05) : 942 - 947
[47] The role of host genetic factors and host immunity in necrotic enteritis
Oh, Sung T.
Lillehoj, Hyun S.
[J]. AVIAN PATHOLOGY, 2016, 45 (03) : 313 - 316
[48] Host Genetic Variation Influences Gene Expression Response to Rhinovirus Infection
Caliskan, Minal
Baker, Samuel W.
Gilad, Yoav
Ober, Carole
[J]. PLOS GENETICS, 2015, 11 (04):
[49] Prevalence and genetic diversity of human rhinovirus among patients with acute respiratory infections in China, 2012-2021
Cui, Aili
Xia, Baicheng
Jiang, Haoran
Li, Qi
Sun, Liwei
Xu, Jin
Hu, Kongxin
Xie, Zhibo
Wang, Yage
Zhu, Runan
Huang, Chaoyang
Li, Zhong
Xu, Jing
Wang, Wenyang
Zhang, Hui
Gao, Zhenguo
Zhang, Feng
Xie, Hui
Zhang, Yan
[J]. JOURNAL OF MEDICAL VIROLOGY, 2024, 96 (04)
[50] Human rhinovirus C infections in pediatric hematology and oncology patients
Loria, Carolina
Domm, Jennifer A.
Halasa, Natasha B.
Heitman, Elizabeth
Miller, E. Kathryn
Xu, Meng
Saville, Benjamin R.
Frangoul, Haydar
Williams, John V.
[J]. PEDIATRIC TRANSPLANTATION, 2015, 19 (01) : 94 - 100

← 1 2 3 4 5 →