Host tissue determinants of tumour immunity

被引：189

作者：

Salmon, Helene ^{[1
,2
,3
,4
]}

Remark, Romain ^{[5
]}

Gnjatic, Sacha ^{[1
,2
,3
,6
]}

Merad, Miriam ^{[1
,2
,3
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Ontol Sci, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Precis Immunol Inst, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA

[4] Inst Curie, INSERM U932, Paris, France

[5] Innate Pharma, Marseille, France

[6] Icahn Sch Med Mt Sinai, Dept Hematol & Oncol, New York, NY 10029 USA

来源：

NATURE REVIEWS CANCER | 2019年 / 19卷 / 04期

关键词：

TERTIARY LYMPHOID STRUCTURES; E-CADHERIN EXPRESSION; NATURAL-KILLER-CELLS; REGULATORY T-CELLS; DENDRITIC CELLS; STROMAL CELLS; PD-1; BLOCKADE; LUNG-CANCER; HIGH-GRADE; MYOFIBROBLASTS CONTRIBUTE;

D O I：

10.1038/s41568-019-0125-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although common evolutionary principles drive the growth of cancer cells regardless of the tissue of origin, the microenvironment in which tumours arise substantially differs across various organ sites. Recent studies have established that, in addition to cell-intrinsic effects, tumour growth regulation also depends on local cues driven by tissue environmental factors. In this Review, we discuss how tissue-specific determinants might influence tumour development and argue that unravelling the tissue-specific contribution to tumour immunity should help the development of precise immunotherapeutic strategies for patients with cancer.

引用

页码：215 / 227

页数：13

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