Ido brings down the pressure in systemic inflammation

被引：18
|
作者：
Hofmann, Franz [1 ]
机构：
[1] Tech Univ Munich, Inst Pharmacol & Toxicol, Forschergrp 923, D-8000 Munich, Germany
来源：
NATURE MEDICINE | 2010年 / 16卷 / 03期
关键词：
NITRIC-OXIDE; INDOLEAMINE 2,3-DIOXYGENASE; ENDOTHELIUM; SEPSIS;
D O I：
10.1038/nm0310-265
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Systemic inflammation results in a life-threatening drop in blood pressure. Targeting known players of blood pressure regulation has so far failed to improve outcomes for individuals with sepsis. But a study points to a regulatory pathway involving the amino acid metabolite kynurenine that may provide new avenues for therapies (pages 279-285).
引用
收藏
页码：265 / 267
页数：4
相关论文
共 50 条
  • [41] Roche brings down curtain on Swiss immunology lab
    Alison Abbott
    Nature, 2000, 405 : 605 - 605
  • [42] Systemic Inflammation
    Maerker-Hermann, E.
    INTERNIST, 2013, 54 (04): : 397 - 398
  • [43] STAMPing down inflammation
    Michael Basson
    Nature Medicine, 2012, 18 (8) : 1193 - 1193
  • [44] IDO drives tumor-promoting, pathogenic inflammation in lung
    Smith, Courtney
    Chang, Mee-Young
    Flick, Hollie
    DuHadaway, James
    Mandik-Nayak, Laura
    Laury-Kleintop, Lisa
    Parker, Katherine
    Beury, Daniel
    Ostrand-Rosenberg, Suzanne
    Prendergast, George C.
    Muller, Alexander J.
    CANCER RESEARCH, 2012, 72
  • [45] IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance
    Munn, David H.
    Mellor, Andrew L.
    TRENDS IN IMMUNOLOGY, 2016, 37 (03) : 193 - 207
  • [46] Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation
    Oh Yoen Kim
    Antoine Monsel
    Michèle Bertrand
    Pierre Coriat
    Jean-Marc Cavaillon
    Minou Adib-Conquy
    Critical Care, 14
  • [47] Differential down-regulation of HLA-DR on monocyte subpopulations during systemic inflammation
    Kim, Oh Yoen
    Monsel, Antoine
    Bertrand, Michele
    Coriat, Pierre
    Cavaillon, Jean-Marc
    Adib-Conquy, Minou
    CRITICAL CARE, 2010, 14 (02):
  • [48] Fires: Torch brings down tank faster than expected
    ENR (Engineering News-Record), 1997, 238 (12):
  • [49] SPACE AGE SATELLITE BRINGS DOWN-TO-EARTH RESULTS
    不详
    GROUND WATER AGE, 1969, 4 (03): : 26 - &
  • [50] Clinical Blood Pressure Phenotypes and Low Grade Systemic Inflammation in African Americans
    Veerabhadrappa, Praveen
    Diaz, Keith M.
    Williamson, Sheara
    Feairheller, Deborah
    Sturgeon, Kathleen
    Brown, Michael D.
    HYPERTENSION, 2011, 58 (05) : E121 - E122
12345