Ido brings down the pressure in systemic inflammation

被引：18

作者：

Hofmann, Franz ^{[1
]}

机构：

[1] Tech Univ Munich, Inst Pharmacol & Toxicol, Forschergrp 923, D-8000 Munich, Germany

来源：

NATURE MEDICINE | 2010年 / 16卷 / 03期

关键词：

NITRIC-OXIDE; INDOLEAMINE 2,3-DIOXYGENASE; ENDOTHELIUM; SEPSIS;

D O I：

10.1038/nm0310-265

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Systemic inflammation results in a life-threatening drop in blood pressure. Targeting known players of blood pressure regulation has so far failed to improve outcomes for individuals with sepsis. But a study points to a regulatory pathway involving the amino acid metabolite kynurenine that may provide new avenues for therapies (pages 279-285).

引用

页码：265 / 267

页数：4

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