Ido brings down the pressure in systemic inflammation

被引：20
|
作者：
Hofmann, Franz [1 ]
机构：
[1] Tech Univ Munich, Inst Pharmacol & Toxicol, Forschergrp 923, D-8000 Munich, Germany
来源：
NATURE MEDICINE | 2010年 / 16卷 / 03期
关键词：
NITRIC-OXIDE; INDOLEAMINE 2,3-DIOXYGENASE; ENDOTHELIUM; SEPSIS;
D O I：
10.1038/nm0310-265
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Systemic inflammation results in a life-threatening drop in blood pressure. Targeting known players of blood pressure regulation has so far failed to improve outcomes for individuals with sepsis. But a study points to a regulatory pathway involving the amino acid metabolite kynurenine that may provide new avenues for therapies (pages 279-285).
引用
收藏
页码：265 / 267
页数：4
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