T-cell immunoglobulin and mucin-domain containing-3 in malignant cancers

被引：2

作者：

Xu, Yun ^{[1
]}

Jiang, Xiping ^{[1
]}

Huang, Yaqing ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 3, Dept Gynecol, 185 Juqian St, Changzhou 213003, Peoples R China

来源：

TRANSLATIONAL CANCER RESEARCH | 2017年 / 6卷 / 03期

关键词：

T-cell immunoglobulin and mucin-domain containing-3 (Tim-3); human cancer; anti-Tim-3; antibody; cancer immunotherapy; 3 GENE POLYMORPHISMS; TIM-3; EXPRESSION; UP-REGULATION; THERAPEUTIC TARGET; POOR-PROGNOSIS; MELANOMA-CELLS; PD-1; DYSFUNCTION; ACTIVATION; EXHAUSTION;

D O I：

10.21037/tcr.2017.05.08

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune checkpoints are one of the key factors comprising the extensive network of the human immune system. Immune checkpoints ensure T-cell homeostasis, activation and differentiation. The checkpoint T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) plays an important role in immune system. Tim-3 is a member of TIM family and can negatively regulate T helper 1 (Th1) immunity. A literature search for Tim-3 was performed via PubMed. It is suggested that the overexpression of Tim-3 is correlated with poorer prognosis for multiple cancers. Co-expression of Tim-3 and other immune checkpoints has been revealed. Blockade of Tim-3 exerts antitumor function and may have synergistic activity being alone or combined with anti-PD-1 antibody or chemotherapy. Thus, Tim-3 is a promising target for cancer immunotherapy.

引用

页码：613 / 619

页数：7

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