T-cell immunoglobulin and mucin-domain containing-3 in malignant cancers

被引：2
|
作者：
Xu, Yun [1 ]
Jiang, Xiping [1 ]
Huang, Yaqing [1 ]
机构：
[1] Soochow Univ, Affiliated Hosp 3, Dept Gynecol, 185 Juqian St, Changzhou 213003, Peoples R China
来源：
TRANSLATIONAL CANCER RESEARCH | 2017年 / 6卷 / 03期
关键词：
T-cell immunoglobulin and mucin-domain containing-3 (Tim-3); human cancer; anti-Tim-3; antibody; cancer immunotherapy; 3 GENE POLYMORPHISMS; TIM-3; EXPRESSION; UP-REGULATION; THERAPEUTIC TARGET; POOR-PROGNOSIS; MELANOMA-CELLS; PD-1; DYSFUNCTION; ACTIVATION; EXHAUSTION;
D O I：
10.21037/tcr.2017.05.08
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immune checkpoints are one of the key factors comprising the extensive network of the human immune system. Immune checkpoints ensure T-cell homeostasis, activation and differentiation. The checkpoint T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) plays an important role in immune system. Tim-3 is a member of TIM family and can negatively regulate T helper 1 (Th1) immunity. A literature search for Tim-3 was performed via PubMed. It is suggested that the overexpression of Tim-3 is correlated with poorer prognosis for multiple cancers. Co-expression of Tim-3 and other immune checkpoints has been revealed. Blockade of Tim-3 exerts antitumor function and may have synergistic activity being alone or combined with anti-PD-1 antibody or chemotherapy. Thus, Tim-3 is a promising target for cancer immunotherapy.
引用
收藏
页码：613 / 619
页数：7
相关论文
共 50 条
  • [31] T-Cell Immunoglobulin- and Mucin-Domain-Containing Molecule 3 Signaling Blockade Improves Cell-Mediated Immunity Against Malaria
    Hou, Nan
    Zou, Yang
    Piao, Xianyu
    Liu, Shuai
    Wang, Lei
    Li, Shanshan
    Chen, Qijun
    JOURNAL OF INFECTIOUS DISEASES, 2016, 214 (10): : 1547 - 1556
  • [32] The T-cell immunoglobulin and mucin domain (Tim) gene family in asthma, allergy, and autoimmunity
    Li, Zhenhong
    Ju, Zhongliang
    Frieri, Marianne
    ALLERGY AND ASTHMA PROCEEDINGS, 2013, 34 (01) : E21 - E26
  • [33] Investigation of T-cell immunoglobulin-and mucin-domain-containing molecule-3 (TIM-3) polymorphisms in essential thrombocythaemia (ET)
    Han, Fuyan
    Wang, Guanghai
    Li, Yuantang
    Tian, Wenjun
    Dong, Zhenfang
    Cheng, Shiqing
    Liu, Yiqing
    Qu, Teng
    Wang, Xiaoying
    Wang, Yong
    Zhang, Bingchang
    Ju, Ying
    HEMATOLOGY, 2017, 22 (06) : 361 - 367
  • [34] Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3)
    Rietz, Tyson A.
    Teuscher, Kevin B.
    Mills, Jonathan J.
    Gogliotti, Rocco D.
    Lepovitz, Lance T.
    Scaggs, W. Rush
    Yoshida, Keisuke
    Luong, Kelvin
    Lee, Taekyu
    Fesik, Stephen W.
    JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (19) : 14757 - 14772
  • [35] Association of T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (Tim-3) Polymorphisms with Susceptibility and Disease Progression of HBV Infection
    Liao, Jingyu
    Zhang, Qi
    Liao, Yun
    Cai, Bei
    Chen, Jie
    Li, Lixin
    Wang, Lanlan
    PLOS ONE, 2014, 9 (05):
  • [36] The inhibition of the T-cell immunoglobulin and mucin domain 3 (Tim3) pathway enhances the efficacy of tumor vaccine
    Lee, Mi Jin
    Woo, Min-Yeong
    Heo, Yoo Mi
    Kim, Jung Sik
    Kwon, Myung-Hee
    Kim, Kyongmin
    Park, Sun
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 402 (01) : 88 - 93
  • [37] T-Cell Immunoglobulin- and Mucin-Domain-Containing Molecule 3 Genetic Variants and HIV plus Non-Hodgkin Lymphomas
    Song, Haihan
    Ma, Shaolin
    Cha, Zhanshan
    Chen, Lei
    Tong, Danian
    Ma, Lan
    Song, Weiguo
    Bai, Jianwen
    INFLAMMATION, 2013, 36 (04) : 793 - 799
  • [38] High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3
    Amit K. Gandhi
    Walter M. Kim
    Zhen-Yu J. Sun
    Yu-Hwa Huang
    Daniel A. Bonsor
    Eric J. Sundberg
    Yasuyuki Kondo
    Gerhard Wagner
    Vijay K. Kuchroo
    Gregory Petsko
    Richard S. Blumberg
    Scientific Reports, 8
  • [39] High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3
    Gandhi, Amit K.
    Kim, Walter M.
    Sun, Zhen-Yu J.
    Huang, Yu-Hwa
    Bonsor, Daniel A.
    Sundberg, Eric J.
    Kondo, Yasuyuki
    Wagner, Gerhard
    Kuchroo, Vijay K.
    Petsko, Gregory
    Blumberg, Richard S.
    SCIENTIFIC REPORTS, 2018, 8
  • [40] The expression of T-cell immunoglobulin and mucin-domain-containing molecule (Tim)-1 and Tim-3 in mice model of experimental colitis
    Xie, Y.
    Zhou, N. J.
    Liu, J. L.
    Tan, Y.
    Liu, W.
    Yan, H.
    Liu, D. S.
    Zhou, X. J.
    Lu, N. H.
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2009, 24 : A58 - A58
12345