2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

被引：70

作者：

Joo, YH ^{[1
]}

Kim, JK ^{[1
]}

Kang, SH ^{[1
]}

Noh, MS ^{[1
]}

Ha, JY ^{[1
]}

Choi, JK ^{[1
]}

Lim, KM ^{[1
]}

Lee, CH ^{[1
]}

Chung, S ^{[1
]}

机构：

[1] AmorePacific Corp, R&D Ctr, Drug Discovery, Yongin 449729, Kyounggi Do, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(02)00952-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：413 / 417

页数：5

共 50 条

[41] Design and synthesis of novel diaryl heterocyclic derivatives as selective cyclooxygenase-2
Li, S. X.
Deng, X. D.
Jiang, F. L.
Zhao, Y. J.
Xiao, W. S.
Kuang, X. Z.
Sun, X. M.
LETTERS IN DRUG DESIGN & DISCOVERY, 2008, 5 (02) : 127 - 133
[42] The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: The first clinical candidate
Wang, Jane L.
Carter, Jeffery
Kiefer, James R.
Kurumbail, Ravi G.
Pawlitz, Jennifer L.
Brown, David
Hartmann, Susan J.
Graneto, Matthew J.
Seibert, Karen
Talley, John J.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (23) : 7155 - 7158
[43] Novel Group of Imidazole Derivatives as Atypical Selective Cyclooxygenase-2 Inhibitors: Design, Synthesis and Biological Evaluation
Kiani, Azin
Rezaee, Elham
Tabatabai, Sayyed Abbas
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2018, 17 : 78 - 86
[44] The design and synthesis of novel cyclooxygenase-2 inhibitors
Woods, KW
McCroskey, RW
Michaelides, MR
Wada, CK
Hulkower, KI
Bell, RL
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 214 : 92 - MEDI
[45] Cyclooxygenase-2 inhibitors
Nies, AS
Gresser, MJ
ADVANCES IN PROTEIN CHEMISTRY, VOL 56: DRUG DISCOVERY AND DESIGN, 2001, 56 : 115 - +
[46] Cyclooxygenase-2 inhibitors
Gajraj, NM
ANESTHESIA AND ANALGESIA, 2003, 96 (06): : 1720 - 1738
[47] Cyclooxygenase-2 inhibitors
Terrett, N
DRUG DISCOVERY TODAY, 1997, 2 (11) : 501 - 501
[48] Cyclooxygenase-2 inhibitors
Hawkey, CJ
Fortun, PJ
CURRENT OPINION IN GASTROENTEROLOGY, 2005, 21 (06) : 660 - 664
[49] Cyclooxygenase-2 inhibitors
Turnheim, K
WIENER KLINISCHE WOCHENSCHRIFT, 2001, 113 (15-16) : 558 - 565
[50] Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum
Zou, J
Jin, DZ
Chen, WL
Wang, J
Liu, QF
Zhu, XZ
Zhao, WM
JOURNAL OF NATURAL PRODUCTS, 2005, 68 (10): : 1514 - 1518

← 1 2 3 4 5 →