2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

被引：70

作者：

Joo, YH ^{[1
]}

Kim, JK ^{[1
]}

Kang, SH ^{[1
]}

Noh, MS ^{[1
]}

Ha, JY ^{[1
]}

Choi, JK ^{[1
]}

Lim, KM ^{[1
]}

Lee, CH ^{[1
]}

Chung, S ^{[1
]}

机构：

[1] AmorePacific Corp, R&D Ctr, Drug Discovery, Yongin 449729, Kyounggi Do, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(02)00952-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：413 / 417

页数：5

共 50 条

[21] Potent and selective cyclooxygenase-2 inhibitors
不详
EXPERT OPINION ON THERAPEUTIC PATENTS, 1997, 7 (01) : 79 - 80
[22] Enantiospecific, selective cyclooxygenase-2 inhibitors
Kozak, KR
Prusakiewicz, JJ
Rowlinson, SW
Marnett, LJ
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (09) : 1315 - 1318
[23] Pyridazinones as selective cyclooxygenase-2 inhibitors
Li, CS
Brideau, C
Chan, CC
Savoie, C
Claveau, D
Charleson, S
Gordon, R
Greig, G
Gauthier, JY
Lau, CK
Riendeau, D
Thérien, M
Wong, E
Prasit, P
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (04) : 597 - 600
[24] A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors
Li, CS
Black, WC
Brideau, C
Chan, CC
Charleson, S
Cromlish, WA
Claveau, D
Gauthier, JY
Gordon, R
Greig, G
Grimm, E
Guay, J
Lau, CK
Riendeau, D
Thérien, M
Visco, DM
Wong, E
Xu, LJ
Prasit, P
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (22) : 3181 - 3186
[25] MOLECULAR DOCKING STUDY OF IBUPROFEN DERIVATIVES AS SELECTIVE INHIBITORS OF CYCLOOXYGENASE-2
Chebrolu, A.
Madhavan, S.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2020, 11 (12): : 6526 - 6531
[26] Isomeric acetoxy analogues of rofecoxib: A novel class of highly potent and selective cyclooxygenase-2 inhibitors
Rahim, MA
Rao, PNP
Knaus, EE
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (19) : 2753 - 2756
[27] 2,3-Diarylpyran-4-ones: a new series of selective cyclooxygenase-2 inhibitors
Joo, YH
Kim, JK
Kang, SH
Noh, MS
Ha, JY
Choi, JK
Lim, KM
Chung, S
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (09) : 2195 - 2198
[28] Natural products and their derivatives as cyclooxygenase-2 inhibitors
Chandel, Priyanka
Rawal, Ravindra K.
Kaur, Rupinder
FUTURE MEDICINAL CHEMISTRY, 2018, 10 (20) : 2471 - 2492
[29] Selective Cyclooxygenase-2 Inhibitors: Design and Synthesis
Xin Sheng LEI
Zong Ru GUO
Ling Bo QU
Qi Qing ZHU(Institute of Materia Medica. Chinese Academy of Medical SciencesAnd Peking Union Medical College. Beijing 100050)
ChineseChemicalLetters, 1999, (06) : 469 - 472
[30] Selective cyclooxygenase-2 inhibitors: Design and synthesis
Lei, XS
Guo, ZR
Qu, LB
Zhu, QQ
CHINESE CHEMICAL LETTERS, 1999, 10 (06) : 469 - 472

← 1 2 3 4 5 →