Phytochemical investigation of labdane diterpenes from the rhizomes of Hedychium spicatum and their cytotoxic activity

被引：37

作者：

Reddy, P. Prabhakar ^{[1
]}

Rao, R. Ranga ^{[1
]}

Shashidhar, J. ^{[2
]}

Sastry, B. S. ^{[1
]}

Rao, J. Madhusudana ^{[1
]}

Babu, K. Suresh ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Nat Prod Lab, Div Organ Chem 1, Hyderabad 500607, Andhra Pradesh, India

[2] Natl Inst Nutr, Div Biochem, Hyderabad 500607, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 21期

关键词：

Hedychium spicatum; Zingiberaceae; Labdane diterpenes; Cytotoxic activity; STEM BARK; IN-VITRO; CONSTITUENTS;

D O I：

10.1016/j.bmcl.2009.09.032

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A comprehensive reinvestigation of chemical constituents from the rhizomes of Hedychium spicatum led to the isolation of two new labdane-type diterpene (1, 2), together with six known compounds (3-8). Their structures were established on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by comparison with the spectroscopic data reported in the literature. In addition, all the isolates were tested for their cytotoxicity against the THP-1 (human acute monocytic leukemia), HL-60 (human promyelocytic leukemia), A-375 (human malignant melanoma) and A-549 (human lung carcinoma) cancerous cell lines. (C) 2009 Published by Elsevier Ltd.

引用

页码：6078 / 6081

页数：4

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