Phytochemical investigation of labdane diterpenes from the rhizomes of Hedychium spicatum and their cytotoxic activity

被引：37

作者：

Reddy, P. Prabhakar ^{[1
]}

Rao, R. Ranga ^{[1
]}

Shashidhar, J. ^{[2
]}

Sastry, B. S. ^{[1
]}

Rao, J. Madhusudana ^{[1
]}

Babu, K. Suresh ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Nat Prod Lab, Div Organ Chem 1, Hyderabad 500607, Andhra Pradesh, India

[2] Natl Inst Nutr, Div Biochem, Hyderabad 500607, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 21期

关键词：

Hedychium spicatum; Zingiberaceae; Labdane diterpenes; Cytotoxic activity; STEM BARK; IN-VITRO; CONSTITUENTS;

D O I：

10.1016/j.bmcl.2009.09.032

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A comprehensive reinvestigation of chemical constituents from the rhizomes of Hedychium spicatum led to the isolation of two new labdane-type diterpene (1, 2), together with six known compounds (3-8). Their structures were established on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by comparison with the spectroscopic data reported in the literature. In addition, all the isolates were tested for their cytotoxicity against the THP-1 (human acute monocytic leukemia), HL-60 (human promyelocytic leukemia), A-375 (human malignant melanoma) and A-549 (human lung carcinoma) cancerous cell lines. (C) 2009 Published by Elsevier Ltd.

引用

页码：6078 / 6081

页数：4

共 50 条

[31] Labdane diterpenes from Aster spathulifolius and their cytotoxic effects on human cancer cell lines
Lee, SO
Choi, SZ
Choi, SU
Lee, KC
Chin, YW
Kim, J
Kim, YC
Lee, KR
JOURNAL OF NATURAL PRODUCTS, 2005, 68 (10): : 1471 - 1474
[32] Labdane-type diterpenes with inhibitory effects on increase in vascular permeability and nitric oxide production from Hedychium coronarium
Matsuda, H
Morikawa, T
Sakamoto, Y
Toguchida, I
Yoshikawa, M
BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (08) : 2527 - 2534
[33] Chemical Composition and Antibacterial Activity of Rhizome Oils From Hedychium coronarium Koenig and Hedychium spicatum Buch-Ham.
Prakash, Om
Rajput, M.
Kumar, Mahesh
Pant, A. K.
JOURNAL OF ESSENTIAL OIL BEARING PLANTS, 2010, 13 (02) : 250 - 259
[34] Phytochemical investigation of sesquiterpenes from the fruits of Schisandra chinensis and their cytotoxic activity
Venkanna, A.
Siva, B.
Poornima, B.
Vadaparthi, P. R. Rao
Prasad, K. Rajendra
Reddy, K. Ashok
Reddy, G. Bhanu Prakash
Babu, K. Suresh
FITOTERAPIA, 2014, 95 : 102 - 108
[35] Antileishmanial Activity of Labdane Diterpenes Isolated from Alpinia nigra Seeds
Ghosh, Sudipta
Singh, Rajesh Kumar
Dubey, Vikash Kumar
Rangan, Latha
LETTERS IN DRUG DESIGN & DISCOVERY, 2017, 14 (01) : 119 - 124
[36] Labdane-Type Diterpenes from Hedychium gardnerianum with Potent Cytotoxicity against Human Small Cell Lung Cancer Cells
Kumrit, Iyared
Suksamrarn, Apichart
Meepawpan, Puttinan
Songsri, Sineenard
Nuntawong, Nuchnipa
PHYTOTHERAPY RESEARCH, 2010, 24 (07) : 1009 - 1013
[37] Antiinflammatory principles and three new labdane-type diterpenes, hedychilactones A, B, and C, from the rhizome of Hedychium coronarium KOENG
Matsuda, H
Morikawa, T
Sakamoto, Y
Toguchida, I
Yoshikawa, M
HETEROCYCLES, 2002, 56 (1-2) : 45 - 50
[38] Phytochemical investigation of the fruits of Xanthium strumarium and their cytotoxic activity
Xiang-Wei Xu
Yi-Yuan Xi
Jun Chen
Feng Zhang
Ju-Jia Zheng
Peng-Hai Zhang
Journal of Natural Medicines, 2022, 76 : 468 - 475
[39] Cardiovascular Activity of Labdane Diterpenes from Andrographis paniculata in Isolated Rat Hearts
Awang, Khalijah
Abdullah, Nor Hayati
Hadi, A. Hamid A.
Fong, Yew Su
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2012,
[40] Comparative study on eucalyptol and camphor rich essential oils from rhizomes of Hedychium spicatum Sm. and their pharmacological, antioxidant and antifungal activities
Rawat, Avneesh
Rawat, Manju
Prakash, Om
Kumar, Ravendra
Punetha, Himanshu
Rawat, Dharmendra S.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, 2022, 94 (03):

← 1 2 3 4 5 →