Ligands of G-quadruplex nucleic acids

被引：19

作者：

Andreev, Dania, V ^{[1
]}

Tikhomirov, Alexander S. ^{[1
,2
]}

Shchekotikhin, Andrey E. ^{[1
,2
]}

机构：

[1] Gause Inst New Antibiot, Pirogovskaya Ul 11, Moscow 119021, Russia

[2] D Mendeleev Univ Chem Technol Russia, Miusskaya Pl 9, Moscow 125047, Russia

来源：

RUSSIAN CHEMICAL REVIEWS | 2021年 / 90卷 / 01期

关键词：

TELOMERIC G-QUADRUPLEX; MYC G-QUADRUPLEX; PROMOTER G-QUADRUPLEX; TUMOR-CELL APOPTOSIS; DNA G-QUADRUPLEX; LIGHT-UP PROBE; STABILIZING LIGANDS; PHENANTHROLINE COMPOUNDS; QUINDOLINE DERIVATIVES; BIOLOGICAL EVALUATION;

D O I：

10.1070/RCR4968

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The review summarizes advances in the development of low-molecular-weight ligands for G-quadruplex (G4) nucleic acid structures published in the past five years. Main chemical classes of these ligands (polyaromatic compounds, macrocyclic systems, metal complexes and heterocyclic derivatives) are considered. The chemical structures of the ligands and their influence on the stabilization of quadruplexes are analyzed. Future prospects of design of G4 ligands and their applications are discussed.

引用

页码：1 / 38

页数：38

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