Ligands of G-quadruplex nucleic acids

被引：19

作者：

Andreev, Dania, V ^{[1
]}

Tikhomirov, Alexander S. ^{[1
,2
]}

Shchekotikhin, Andrey E. ^{[1
,2
]}

机构：

[1] Gause Inst New Antibiot, Pirogovskaya Ul 11, Moscow 119021, Russia

[2] D Mendeleev Univ Chem Technol Russia, Miusskaya Pl 9, Moscow 125047, Russia

来源：

RUSSIAN CHEMICAL REVIEWS | 2021年 / 90卷 / 01期

关键词：

TELOMERIC G-QUADRUPLEX; MYC G-QUADRUPLEX; PROMOTER G-QUADRUPLEX; TUMOR-CELL APOPTOSIS; DNA G-QUADRUPLEX; LIGHT-UP PROBE; STABILIZING LIGANDS; PHENANTHROLINE COMPOUNDS; QUINDOLINE DERIVATIVES; BIOLOGICAL EVALUATION;

D O I：

10.1070/RCR4968

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The review summarizes advances in the development of low-molecular-weight ligands for G-quadruplex (G4) nucleic acid structures published in the past five years. Main chemical classes of these ligands (polyaromatic compounds, macrocyclic systems, metal complexes and heterocyclic derivatives) are considered. The chemical structures of the ligands and their influence on the stabilization of quadruplexes are analyzed. Future prospects of design of G4 ligands and their applications are discussed.

引用

页码：1 / 38

页数：38

共 50 条

[21] Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids
Neidle, Stephen
PHARMACEUTICALS, 2022, 15 (01)
[22] A hitchhiker's guide to G-quadruplex ligands
Monchaud, David
Teulade-Fichou, Marie-Paule
ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (04) : 627 - 636
[23] G-Quadruplex Structures and Their Interaction Diversity with Ligands
Zhang, Sulin
Wu, Yanling
Zhang, Wen
CHEMMEDCHEM, 2014, 9 (05) : 899 - 911
[24] A new method for the study of G-quadruplex ligands
Kong, De-Ming
Wu, Jing
Ma, Yong-E
Shen, Han-Xi
ANALYST, 2008, 133 (09) : 1158 - 1160
[25] Development of new fluorescent G-quadruplex ligands
Livendahl, Madeleine
Chorell, Erik
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
[26] G-quadruplex ligands as potent regulators of lysosomes
Ferret, Lucille
Alvarez-Valadez, Karla
Riviere, Jennifer
Muller, Alexandra
Bohalova, Natalia
Yu, Luo
Guittat, Lionel
Brazda, Vaclav
Kroemer, Guido
Mergny, Jean-Louis
Djavaheri-Mergny, Mojgan
AUTOPHAGY, 2023, 19 (07) : 1901 - 1915
[27] Screening of Scaffolds for the Design of G-Quadruplex Ligands
Figueiredo, Joana
Peitinho, David
Campello, Maria Paula Cabral
Oliveira, Maria Cristina
Paulo, Antonio
Mergny, Jean-Louis
Cruz, Carla
APPLIED SCIENCES-BASEL, 2022, 12 (04):
[28] Colorimetric and fluorescence detection of G-quadruplex nucleic acids with a coumarin-benzothiazole probe
Yan, Jin-wu
Tian, Yi-guang
Tan, Jia-heng
Huang, Zhi-shu
ANALYST, 2015, 140 (21) : 7146 - 7149
[29] The Design of G-quadruplex Ligands as Telomerase Inhibitors
Cuesta, Javier
Read, Martin A.
Neidle, Stephen
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2003, 3 (01) : 11 - 21
[30] Nucleic acids in anhydrous media: G-quadruplex folding governed by Kramers rate theory
Mamajanov, Irena
Lannan, Ford M.
Hud, Nicholas V.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2013, 31 : 29 - 30

← 1 2 3 4 5 →