Long-term effect of a single dose of flunarizine in Huntington's disease

被引：2
|
作者：
Belfiore, G
Di Maio, L
Napolitano, G
Cella, S
Filla, A
De Michele, G
Campanella, G
机构：
[1] Univ Naples Federico II, Neurol Clin, Dept Neurol Sci, I-80131 Naples, Italy
[2] Osped Civile Vito Fazzi, Dept Neurol, Lecce, Italy
[3] Mediterranean Neurol Inst NEUROMED, Pozzilli, Italy
来源：
EUROPEAN JOURNAL OF NEUROLOGY | 1998年 / 5卷 / 03期
关键词：
Huntington's disease; flunarizine therapy;
D O I：
10.1046/j.1468-1331.1998.530249.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We report a preliminary pilot study on the clinical efficacy of flunarizine (FNZ), a calcium-entry blocker that causes extrapyramidal side-effects, in 10 patients with Huntington's disease (HD). FNZ (20 mg) administered by the sublingual route resulted in a decrease in choreic movements and improved dexterity in performing several tests. These effects lasted for at least 7 days after a single dose. Therefore, FNZ seems to exert the same effect as a long-acting neuroleptic agent in our HD patients. (C) 1998 Lippincott-Raven Publishers.
引用
收藏
页码：249 / 253
页数：5
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